59857-63-5Relevant articles and documents
HYDROLYSIS OF FLUOROALKYL-CONTAINING β-AMINOVINYL KETONES
Bazhenova, L. N.,Filyakova, V. I.,Kirichenko, V. E.,Pashkevich, K. I.
, p. 581 - 585 (2007/10/02)
The kinetics of hydrolysis of fluoroalkyl-containing β-aminovinyl ketones R1C(O)CHC(NHR3)R2, in which the substituents CF3 and HCF2CF2 are in the ketone (R1) or enamine parts of the molecule (R2), was studied.In acid (pH 10) media, they hydrolyze with the formation of the corresponding amines and β-diketones.In an alkaline medium, the β-diketones undergo cleavage to fluorinated acids and methyl ketones.The rate constants of hydrolysis in an acid medium change within a range of four orders, depensdng on the nature of the substituents.The presence of a fluoroalkyl group at the enamine reaction center increases the hydrolysis rate.In an alkaline medium, the rate constants vary within one order.
