59864-30-1 Usage
Description
2,4-Dimethoxypyrimidine-6-carboxylic acid is an organic compound with the molecular formula C6H6N2O4. It is a key intermediate in the synthesis of various chemical compounds, particularly in the pharmaceutical and chemical industries. Its structure features two methoxy groups attached to the pyrimidine ring and a carboxylic acid group at the 6th position, which allows for further chemical reactions and modifications.
Uses
Used in Pharmaceutical Industry:
2,4-Dimethoxypyrimidine-6-carboxylic acid is used as a reactant or reagent for the synthetic preparation of racemic cylindrospermopsin, a potent cyanotoxin that has been linked to various health issues in humans and animals. The synthesis of this compound is crucial for research purposes, as it helps in understanding the structure-activity relationship and developing potential antidotes or treatments for cylindrospermopsin poisoning.
Additionally, due to its unique chemical structure, 2,4-dimethoxypyrimidine-6-carboxylic acid may also be utilized in the development of other pharmaceutical compounds with potential therapeutic applications. Its ability to form various derivatives and participate in different chemical reactions makes it a versatile building block in the synthesis of novel drugs.
Used in Chemical Industry:
In the chemical industry, 2,4-dimethoxypyrimidine-6-carboxylic acid can be employed as a starting material for the synthesis of a wide range of compounds with diverse applications. These may include agrochemicals, dyes, and other specialty chemicals. Its reactivity and functional groups make it a valuable component in the development of new products and processes within the industry.
Check Digit Verification of cas no
The CAS Registry Mumber 59864-30-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,8,6 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59864-30:
(7*5)+(6*9)+(5*8)+(4*6)+(3*4)+(2*3)+(1*0)=171
171 % 10 = 1
So 59864-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O4/c1-12-5-3-4(6(10)11)8-7(9-5)13-2/h3H,1-2H3,(H,10,11)
59864-30-1Relevant articles and documents
Total synthesis of (±)-cylindrospermopsin
Xie, Chaoyu,Runnegar, Maria T. C.,Snider, Barry B.
, p. 5017 - 5024 (2007/10/03)
The first total synthesis of the novel hepatotoxin (±)- cylindrospermopson (1) has been accomplished in 20 steps from 4-methoxy-3- methylpyridine (12) in 3.5% overall yield. The substituted piperidine A ring 19 was generated stereospecifically by a four-step sequence using the addition of trimethylsilylethynylmagnesium bromide to 12 to give 16 and stereospecific addition of vinylcuprate to 16 to form 17. The reaction of diamine 26 with cyanogen bromide produced the cyclic guanidine C ring of 27. The key step in the synthesis was bromination of ketone 31, followed by hydrogenation to liberate the free guanidine, which underwent an intramolecular S(N)2 reaction to form the tetrahydropyrimidine ring B of 32. Further hydrogenation reduced the ketone to yield 42% of 32 containing the fully functionalized tricyclic system and protected hydroxymethyluracil side chain of cylindrospermopsin. Hydrolysis of the pyrimidine in concentrated hydrochloric acid and selective monosulfation completed the synthesis of cylindrospermopsin.
