59874-81-6

Basic information

• Product Name: Ethanimidic acid, 2,2,2-trichloro-, 3-phenyl-2-propenyl ester, (E)-
• CAS NO: 59874-81-6
• Molecular Formula: C11H10Cl3NO
• Molecular Weight: 278.565
• Mol File: 59874-81-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanimidic acid, 2,2,2-trichloro-, 3-phenyl-2-propenyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanimidic acid, 2,2,2-trichloro-, 3-phenyl-2-propenyl ester, (E)-(59874-81-6)
• EPA Substance Registry System: Ethanimidic acid, 2,2,2-trichloro-, 3-phenyl-2-propenyl ester, (E)-(59874-81-6)

Safety Data

• Hazardous Substances Data: 59874-81-6(Hazardous Substances Data)

Upstream product

• 545-06-2 trichloroacetonitrile 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 131120-92-8 (E)-2,2,2-trichloro-N-cinnamylacetamide 
• 244092-75-9 (1S)-1-phenyl-2-propen-1-amine 
• 688362-68-7 (R)-(+)-N-acetyl-1-phenylprop-2-enylamine 
• 484051-35-6 rac-1-[N-(1'-phenyl-prop-2'-enyl)amino]methyl-2,4-dimethoxybenzene 
• 4393-21-9 1-(phenyl)allylamine 
• 373362-00-6 N,N-diethyl-1-phenylprop-2-en-1-amine 
• 1181394-16-0 1-phenylprop-2-en-1-amine hydrochloride 
• 59874-90-7 N-<1-(1-phenylprop-2-enyl)> trichloroacetamide 

Relevant articles and documents

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY BASED ON AROMATIC ALLYL AMINES

New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.

An access to (Z)-ethylenic pseudodipeptides based on ring-closing metathesis

A new access to enantiopure (Z)-ethylenic pseudopeptides, starting from the chiral pool of amino acids and enantiopure 2-substituted-but-3-enoic acids is proposed and illustrated by the syntheses of the (Z)-ethylenic pseudopeptidic analogs of L-Phe-L-Phe, L-Phe-D-Phe, L-Phe-L-Val, L-Phe-D-Val and racemic (LL,DD) and (LD,DL) (phenyl)Gly-Phe. The key-steps of these syntheses are a ring-closing metathesis, catalysed by Grubbs' ruthenium alkykidene complexes, on diethylenic amides and the hydrolytic cleavage of the resulting dihydropyridones under mild conditions through intermediate formation of cyclic imidates.