59875-04-6

Basic information

• Product Name: 2-Butyrylaminopropinicacid
• Synonyms: 2-Butyrylaminopropinicacid;Alanin, N-(1-oxobutyl)-;2-Butyramidopropanoic acid;DL-Alanine, N-(1-oxobutyl)-;2-((Butanoyl)amino)propanoic acid;N-(1-Oxobutyl)alanine;N-(1-Oxobutyl)-DL-alanine;Alanine,N-(1-oxobutyl)-
• CAS NO: 59875-04-6
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• EINECS: 1592732-453-0
• Mol File: 59875-04-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• Appearance: /
• Density: 1.097
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: DMSO, Methanol
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: 2-Butyrylaminopropinicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyrylaminopropinicacid(59875-04-6)
• EPA Substance Registry System: 2-Butyrylaminopropinicacid(59875-04-6)

Safety Data

• Hazardous Substances Data: 59875-04-6(Hazardous Substances Data)

Usage

Description

2-Butyrylaminopropinic acid, also known as N-(1-Oxobutyl)-DL-alanine, is an organic compound that serves as a crucial reactant in the pharmaceutical industry. It is characterized by its unique chemical structure, which allows it to participate in various chemical reactions and contribute to the synthesis of different compounds.

Uses

Used in Pharmaceutical Industry:
2-Butyrylaminopropinic acid is used as a reactant for the preparation of Vardenafil (V098001, 2HCl salt), a selective phosphodiesterase type 5 (PDE5) inhibitor. This application is significant because Vardenafil is a widely used medication for the treatment of erectile dysfunction, helping to improve blood flow to the penis and facilitating an erection in response to sexual stimulation. By acting as a reactant in the synthesis of Vardenafil, 2-Butyrylaminopropinic acid plays a vital role in the development of this therapeutic agent, ultimately contributing to the improvement of patients' quality of life and overall well-being.

InChI:InChI=1/C7H13NO3/c1-3-4-6(9)8-5(2)7(10)11/h5H,3-4H2,1-2H3,(H,8,9)(H,10,11)

Upstream product

• 56-41-7 L-alanin 
• 141-75-3 butyryl chloride 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 1134191-22-2 4-(5-thioxo-5H-1,2-dithiol-3-yl)phenyl 2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetate 
• 1134191-27-7 2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetic acid 
• 1134191-30-2 C₂₅H₃₄N₆O₆S 
• 224789-26-8 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonic acid chloride 
• 224789-21-3 2-(2-ethoxyphenyl)-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 224785-90-4 vardenafil 
• 224789-21-3 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 927690-90-2 N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide 

Relevant articles and documents

NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT

Novel compounds for use in cognition improvement It relates to certain compounds having a polycyclic structure and a -(C=O)NRaRb moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases.

N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure.

N-{1-Y3-(2-ETHOXY-5-(4-ETHYLPIPERAZINYL)BENZENESULFONYL)-4,5-DIHYDRO-5-OXO-1,2,4-TRIAZIN-6-YL¨ETHYL}BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure.