599191-02-3

Basic information

• Product Name: tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxo-6-(phenylsulfonyl)hexanoate
• Synonyms: tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxo-6-(phenylsulfonyl)hexanoate
• CAS NO: 599191-02-3
• Molecular Weight: 475.563
• Mol File: 599191-02-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxo-6-(phenylsulfonyl)hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxo-6-(phenylsulfonyl)hexanoate(599191-02-3)
• EPA Substance Registry System: tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxo-6-(phenylsulfonyl)hexanoate(599191-02-3)

Safety Data

• Hazardous Substances Data: 599191-02-3(Hazardous Substances Data)

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 81470-51-1 tert-butyl N-benzyloxycarbonyl-L-pyroglutamate 

Downstream Products

• 599191-10-3 tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxohexanoate 

Relevant articles and documents

New Diastereoselective Route to 2-Substituted cis-(2S,5S)- and trans-(2S,5R)-5-Alkylpyrrolidines as Indolizidine and Pyrrolizidine Scaffolds

A new and short stereoselective route to the synthesis of enantiopure cis-2,5-disubstituted pyrrolidines as indolizidine or pyrrolizidine scaffolds has been developed. The method, which uses (S)-pyroglutamic acid as a chiral starting material, is based on the ring opening of N-protected 7-lactams by alkyl phenyl sulfone carbanions, followed by desulfonylation and reductive amination of alkyl 7-amino ketones. The diastereoselectivity depends on the substitution of the starting γ-lactams, and on the alkyl group of the phenyl sulfone. Total cis diastereoselectivity was observed in the formation of tert-butyl 5-alkylprolinates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.