59981-63-4

Basic information

• Product Name: L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID
• Synonyms: L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID;4,5,6,7-TETRAHYDRO-1H-IMIDAZOL[4,5-C]PYRIDINE-6-CARBOXYLIC ACID;SPINACINE;(S)-4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid;4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine-6α-carboxylic acid;(S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;L-4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid≥ 99% (Assay by titration)
• CAS NO: 59981-63-4
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.17
• Product Categories: Miscellaneous Natural Products
• Mol File: 59981-63-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 552.2°C at 760 mmHg
• Flash Point: 287.8°C
• Appearance: /
• Density: 1.439g/cm³
• Vapor Pressure: 4.99E-13mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: 2-8°C
• PKA: pK1:1.649(+2);pK2:4.936(+1);pK3:8.663(0) (25°C)
• CAS DataBase Reference: L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID(59981-63-4)
• EPA Substance Registry System: L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID(59981-63-4)

Safety Data

• Hazardous Substances Data: 59981-63-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 564, 1984 DOI: 10.1021/jm00371a002

InChI:InChI=1/C7H9N3O2/c11-7(12)5-1-4-6(2-8-5)10-3-9-4/h3,5,8H,1-2H2,(H,9,10)(H,11,12)

Upstream product

• 50-00-0 formaldehyd 
• 71-00-1 L-histidine 
• 71-00-1 L-histidine 

Downstream Products

• 59969-90-3 (S)-5-hydroxymethyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid 
• 156335-71-6 6-(trifluoromethyl)-1H-imidazo<4,5-c>pyridine 
• 133807-88-2 (S)-4,5,6,7-tetrahydro-5-<(phenylamino)carbonyl>-3H-imidazo<4.5-c>pyridine-6-carboxylic acid 
• 133807-90-6 (S)-5-benzoyl-4,5,6,7-tetrahydro-3H-imidazo<4.5-c>pyridine-6-carboxylic acid 
• 114786-39-9 spinacine methyl ester dihydrochloride 

Relevant articles and documents

The Pictet-Spengler reaction on L-histidine. Preparation of conformationally restricted (+)-pilocarpine analogs

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Preparation, activity and application of theanine tetrahydroimidazopyridine-6-formylglycine and alanine

The invention discloses a preparation method of (6S)-5-theanine acyl-4, 5, 6, 7-tetrahydro-3H-imidazole [4, 5-c] pyridin-6-formyl AA (AA is glycine residue and L-alanine residue), discloses a preparation method of the compounds, antithrombotic activity of the compounds, thrombolytic activity of the compounds and treatment effect of the compounds on ischemic stroke for 24 hours. Therefore, the invention discloses application of the compounds in preparation of antithrombotic medicines, thrombolytic medicines and medicines for treating ischemic stroke for 24 hours.

Hexacyclic piperazinedione compound and preparation, biological activity and application thereof

The invention discloses a hexacyclic piperazinedione compound as shown in the following formula: tetrahydro-beta-carboline [3: 4] piperazine-2, 5-diketopiperidine [4: 5] imidazole. The invention discloses a preparation method and application thereof. The compound not only has an anti-tumor proliferation effect, but also can inhibit migration and invasion of tumor cells, and also has an in-vivo anti-metastasis effect.