59995-64-1 Usage
Description
Thienamycin, a potent naturally produced antibiotic, is known for its exceptional activity against a wide range of bacteria, including both Gram-positive and Gram-negative types. It is also notable for its resistance to bacterial β-lactamase enzymes, which makes it a valuable asset in the fight against antibiotic-resistant infections.
Uses
Used in Pharmaceutical Industry:
Thienamycin is used as an antibiotic for treating various bacterial infections. Its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, coupled with its resistance to β-lactamase enzymes, makes it an effective choice for combating a variety of infections, including those caused by antibiotic-resistant strains.
Used in Research and Development:
In the field of medical research, Thienamycin serves as a valuable compound for studying the mechanisms of antibiotic action and resistance. Its unique properties can be harnessed to develop new drugs or improve existing ones, potentially leading to more effective treatments for bacterial infections.
Used in Hospital Settings:
Thienamycin is utilized in hospitals and healthcare facilities as a potent antibiotic for the treatment of severe or life-threatening bacterial infections. Its effectiveness against a wide range of bacteria and resistance to bacterial enzymes make it a crucial tool in the management of complex and challenging infections.
Check Digit Verification of cas no
The CAS Registry Mumber 59995-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,9,9 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 59995-64:
(7*5)+(6*9)+(5*9)+(4*9)+(3*5)+(2*6)+(1*4)=201
201 % 10 = 1
So 59995-64-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O4S/c1-5(14)8-6-4-7(18-3-2-12)9(11(16)17)13(6)10(8)15/h5-6,8,14H,2-4,12H2,1H3,(H,16,17)/t5-,6-,8-/m1/s1
59995-64-1Relevant articles and documents
Antibiotic synthesis
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, (2008/06/13)
A method of preparing intermediates for carbapenem antibiotics characterized by treating a N-deprotected acetoxy conpound of the formula: STR1 in the presence of a Lewis acid or a silylating agent to yeild an intermediate; and cyclizing the intermediate in the presence of rhodium (II) acetate to form a bicyclic ketoester.
N-acyl derivatives of thienamycin
-
, (2008/06/13)
Disclosed are N-acyl derivatives of the antibiotic thienamycin having the following structural formula: STR1 wherein R1 and R2 are independently selected from the group consisting of hydrogen and acyl. Such derivatives and their pharmaceutically acceptable salts, are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
AN ENANTIOSELECTIVE APPROACH TO CARBAPENEM ANTIBIOTICS: FORMAL SYNTHESIS OF (+)-THIENAMYCIN
Hart, David J.,Ha, Deok-Chan
, p. 5493 - 5496 (2007/10/02)
An enantioselective synthesis of intermediates in synthesis of thienamycin (15) and epithienamycin-C (16) is described.