60-25-3 Usage
Description
Hexamethonium Chloride is a white, crystalline, hygroscopic powder with a faint odor. It is a ganglionic nicotinic receptor blocker that forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. It is an allosteric and transmembrane protein localized to the neuromuscular junction. It is very soluble in water, soluble in alcohol, methanol, and n-propanol, and insoluble in chloroform and ether. It is available commercially as an unhydrated form or as a dihydrate.
Uses
Used in Medicine (Antihypertensive):
Hexamethonium Chloride is used as an antihypertensive agent for treating high blood pressure. It blocks the responses of nicotinic receptors towards their agonists, which helps in reducing blood pressure.
Used in Neurophysiology Research:
Hexamethonium Chloride is used as a research tool for studying the mechanosensitivity of viscerofugal neurons. By blocking the ganglionic nicotinic receptors, it aids in understanding the role of these receptors in neuronal function and response to stimuli.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Hexamethonium Chloride is used as an active pharmaceutical ingredient for the development of drugs targeting nicotinic acetylcholine receptors. Its ability to block these receptors makes it a valuable compound in the creation of medications for various conditions related to the nervous system.
Biochem/physiol Actions
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.
Check Digit Verification of cas no
The CAS Registry Mumber 60-25-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60-25:
(4*6)+(3*0)+(2*2)+(1*5)=33
33 % 10 = 3
So 60-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H30N2.2ClH.H2O/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;;/h7-12H2,1-6H3;2*1H;1H2/q+2;;;/p-2
60-25-3Relevant articles and documents
Solid-state synthesis of mixed trihalides via reversible absorption of dihalogens by non porous onium salts
Meazza, Lorenzo,Marti-Rujas, Javier,Terraneo, Giancarlo,Castiglioni, Chiara,Milani, Alberto,Pilati, Tullio,Metrangolo, Pierangelo,Resnati, Giuseppe
experimental part, p. 4427 - 4435 (2012/05/19)
1,6-Bis(trimethylammonium)hexane bis(trihalides) and mixed bis(trihalides) have been synthesized by treating the corresponding dihydrated halides with molecular dihalogens under gas-solid and solution conditions. Despite the starting halides being non-porous, the trihalide syntheses occur homogeneously, in quantitative yields, and reversibly. In all cases halogen bond prevails over hydrogen bond, dihalogens substitute for the hydration water of starting halide anions and trihalides are formed. The stability of the obtained trihalides is mainly due to cooperative halogen bond and cation templation effect. Hexamethonium halides are proven effective solids for the clathration and storage of molecular dihalogens. While the starting salts are not isostructural, all the formed trihalides and mixed trihalides are isostructural.
