6001-64-5 Usage
Description
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, also known as chlorobutanol, is a white crystalline solid with unique chemical properties. It is known for its ability to convert benzisoxazole to α-aryloxyisobutyric acid and form a eutectic with dimethyl sulfone, which is highly beneficial in various applications.
Uses
Used in Pharmaceutical Industry:
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate is used as a solvent for the freeze-drying of certain parenteral organic drugs. Its combination with dimethyl sulfone serves as an appropriate medium for this process, enhancing the stability, dissolution rate, dosing accuracy, and sterility of the drugs.
Used in Chemical Synthesis:
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate is used as a reagent in the conversion of benzisoxazole to α-aryloxyisobutyric acid, a process that is crucial in the synthesis of various chemical compounds.
Used in Freeze-Drying Process:
In the freeze-drying industry, 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate is used as a component in the formation of eutectic with dimethyl sulfone. This eutectic mixture is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal, making it an essential component in the production of freeze-dried products.
Biochem/physiol Actions
Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.
Check Digit Verification of cas no
The CAS Registry Mumber 6001-64-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,0 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6001-64:
(6*6)+(5*0)+(4*0)+(3*1)+(2*6)+(1*4)=55
55 % 10 = 5
So 6001-64-5 is a valid CAS Registry Number.
InChI:InChI=1/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2
