600151-58-4

Basic information

• Product Name: 2-Propen-1-one, 1-[2-hydroxy-3-(2-propenyl)phenyl]-3-(3-methylphenyl)-
• CAS NO: 600151-58-4
• Molecular Formula: C19H18O2
• Molecular Weight: 278.351
• Mol File: 600151-58-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-[2-hydroxy-3-(2-propenyl)phenyl]-3-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-[2-hydroxy-3-(2-propenyl)phenyl]-3-(3-methylphenyl)-(600151-58-4)
• EPA Substance Registry System: 2-Propen-1-one, 1-[2-hydroxy-3-(2-propenyl)phenyl]-3-(3-methylphenyl)-(600151-58-4)

Safety Data

• Hazardous Substances Data: 600151-58-4(Hazardous Substances Data)

Upstream product

• 58621-39-9 2-acetyl-6-allylphenol 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 600151-76-6 8-allyl-3-methoxy-2-m-tolyl-chromen-4-one 
• 600151-66-4 8-allyl-3-hydroxy-2-m-tolyl-chromen-4-one 

Relevant articles and documents

Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid

New analogues of flavone-8-acetic acid were synthesized, bearing an alkoxy group in position 3 and different substituents on the benzene ring in position 2 of the flavone nucleus. The compounds were tested for direct cytotoxicity against four human tumor cell lines and for indirect antitumor effects by measuring their ability to enhance lytic properties of murine macrophages and human monocytes. Though direct toxicity was very low, the compounds were able to induce significant indirect toxicity. Notably, most of them (4c, 4d, 4e, 4f, 4h, 4i, 4m, 4n, and 4o) showed important activity on human monocytes and could be regarded as the first flavone derivatives endowed with such activity. Particularly interesting seem to be compounds 4m and 4n, which showed IC 50 values up to 7 times higher than DMXAA, which has now completed phase I clinical trials.