600732-10-3

Basic information

• Product Name: Thiazole, 2-(2-methylpropyl)-5-phenyl-
• CAS NO: 600732-10-3
• Molecular Formula: C13H15NS
• Molecular Weight: 217.335
• Mol File: 600732-10-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Thiazole, 2-(2-methylpropyl)-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-(2-methylpropyl)-5-phenyl-(600732-10-3)
• EPA Substance Registry System: Thiazole, 2-(2-methylpropyl)-5-phenyl-(600732-10-3)

Safety Data

• Hazardous Substances Data: 600732-10-3(Hazardous Substances Data)

Upstream product

• 107-85-7 1-amino-3-methylbutane 
• 122-78-1 phenylacetaldehyde 
• 591-50-4 iodobenzene 
• 18640-74-9 2-isobutylthiazole 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 

Relevant articles and documents

Palladium-catalyzed direct arylation of thiazoles with aryl bromides

Thiazole, 2-phenyl or -alkyl substituted one and benzothiazole are efficiently arylated with aryl bromides at the 2- and/or 5-position(s) in the presence of Pd(OAc)2 and a bulky phosphine ligand using Cs2CO3 as base. 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4- and 5-positions accompanied by decarbamoylation.

C[sbnd]H Bond activation of 2-isobutylthiazole at C5 position catalysed by Pd-N-heterocyclic carbene complexes

A highly efficient and effective protocol has been developed for the synthesis of C5-(hetero)arylated 2-isobutylthiazole derivatives. Four different palladium N-heterocyclic carbene (Pd-NHCs) complexes [Pd(μ-Cl)Cl(SIMes)]2 (2), (LCl2Pd-SIMes) (3: L = PPh3; 4: L = Py; 5: L = 3-CHO-Py) were synthesized and used for the first time as a catalysts in direct C-H arylation reaction of 2-isobutylthiazole at C5 position. Utilizations of these catalytic systems, the arylation of 2-isobutylthiazole with substituted (hetero)aryl bromides efficiently proceeded at low catalyst loading (1mol%) and without any additives such as PivOH under argon or aerobic conditions at 120 °C in a short time. Different substituted (hetero)aryl bromides, even some deactivated or highly sterically hindered (hetero)arylbromides, with a wide range of functional groups were successfully utilized under the optimum reaction conditions. In all cases, the C5 arylated 2-isobutylthiazoles were obtained in moderate to excellent yields.

Palladium (II) acetate-butyldi-1-adamantylphosphine catalyzed arylation of electron-rich heterocycles. Preparation of 5-phenyl-2-isobutylthiazole

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