600740-48-5Relevant articles and documents
Artificial model for cystathionine β-synthase: Efficient β-replacement reaction with thiols employing a novel pyridoxal model compound having an imidazole function
Miyashita, Kazuyuki,Murafuji, Hidenobu,Iwaki, Hiroshi,Yoshioka, Eito,Imanishi, Takeshi
, p. 4873 - 4879 (2007/10/03)
As a second-generation pyridoxal model compound for cystathionine β-synthase, we designed a novel model compound having an ionophore function and an imidazole function, application of which to the β-replacement reaction with various thiols smoothly took place to give S-substituted cysteines. Peptides having a serine-O-carbonate residue at the N-terminal position were also converted to the corresponding peptides having an S-substituted cysteine residue under the catalytic conditions of the novel pyridoxal model compound.
