601-75-2

Basic information

• Product Name: ETHYLMALONIC ACID
• Synonyms: 2-ethylpropanedioic acid;Ethylpropanedioic acid.;Ethylmalonic acid,97%;Ethylmalonic acid 97%;ETHYLMALONIC ACID;2-CARBOXY BUTYRIC ACID;RARECHEM DK HD C012;1,1-Propanedicarboxylic acid
• CAS NO: 601-75-2
• Molecular Formula: C₅H₈O₄
• Molecular Weight: 132.11
• EINECS: 210-007-2
• Product Categories: Pharmaceutical Intermediates;Miscellaneous;Carboxylic Acid Monomers;Monomers;Polymer Science;C1 to C5;Carbonyl Compounds;Carboxylic Acids
• Mol File: 601-75-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 112-114 °C(lit.)
• Boiling Point: 292.77°C (rough estimate)
• Flash Point: 162.9 °C
• Appearance: white to faintly pink crystalline powder
• Density: 1.5633 (rough estimate)
• Vapor Pressure: 5.83E-05mmHg at 25°C
• Refractive Index: 1.4016 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: pK1:2.90(0);pK2:5.55(+1) (25°C)
• Water Solubility: Soluble in water, methanol (very faint turbidity), and ethanol.
• BRN: 774334
• CAS DataBase Reference: ETHYLMALONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYLMALONIC ACID(601-75-2)
• EPA Substance Registry System: ETHYLMALONIC ACID(601-75-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 601-75-2(Hazardous Substances Data)

Usage

Description

Ethylmalonic acid is an important organic intermediate with a versatile chemical structure that allows it to be utilized in various applications across different industries.

Uses

Used in Agrochemical Industry:
Ethylmalonic acid is used as a key intermediate for the synthesis of various agrochemicals, such as pesticides and herbicides, due to its ability to form stable and effective compounds that can protect crops from pests and diseases.
Used in Pharmaceutical Industry:
Ethylmalonic acid serves as a crucial building block in the development of pharmaceutical compounds, contributing to the creation of drugs with specific therapeutic properties. Its unique structure allows for the design of molecules that can target and treat a wide range of medical conditions.
Used in Dye Industry:
Ethylmalonic acid is used as a vital component in the production of dyes, particularly in the synthesis of colorants for various applications. Its chemical properties enable the creation of dyes with desirable characteristics, such as color intensity, stability, and resistance to fading.

InChI:InChI=1/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9)/p-2

Upstream product

• 3378-01-6 diethyl (acetyl)ethylmalonate 
• 141-52-6 sodium ethanolate 
• 79-37-8 oxalyl dichloride 
• 141-75-3 butyryl chloride 
• 133-13-1 ethyl diethyl malonate 
• 996-82-7 sodium diethylmalonate 
• 506-77-4 cyanogen chloride 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 6148-64-7 ethyl potassium malonate 
• 26717-67-9 dimethyl ethylmalonate 
• 36832-92-5 1,3-diethyl-2,4-dioxo-cyclobutane-1,3-dicarboxylic acid diethyl ester 
• 872819-81-3 2-ethyl-2-cyano-3-oxo-4-phenyl-butyric acid ethyl ester 
• 129867-59-0 bromoethylmalonic acid 
• 7732-18-5 water 

Downstream Products

• 53086-41-2 (E)-2-(4-methoxybenzylidene)butanoic acid 
• 56239-07-7 4-acetamido-5-phenylpyrimidine 
• 109113-91-9 2,6-dihydroxy-3-methyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-88-4 4-oxo-3-methyl-2-acetoxy-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-92-0 2,6-dihydroxy-3-ethyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-89-5 4-oxo-3-ethyl-2-acetoxy-9-phenylpyrimido<1,6-a>pyrimidine 
• 16855-58-6 S,S'-diphenyl 2-ethyldithiomalonate 
• 124-38-9 carbon dioxide 
• 802294-64-0 propionic acid 
• 6423-43-4 1,2-propyl dinitrate 
• 26197-64-8 (E)-2-benzylidenebutanoic acid 
• 55557-24-9 bis(trimethylsilyl) 2-ethylmalonate 
• 24737-96-0 4-ethyl-6-phenyl-4,5-dihydro-3(2H)-pyridazinone 
• 24737-97-1 4-ethyl-6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone 

Relevant articles and documents

Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution. Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones through a Michael addition.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Copper-catalyzed intermolecular chloro- and bromotrifluoromethylation of alkenes

A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.