60144-30-1Relevant articles and documents
Synthesis of α-hydroxyhydrazones from aldehydes
Fernández,Martín-Zamora,Pareja,Alcarazo,Martín,Lassaletta
, p. 1158 - 1160 (2001)
The 1,2-addition of formaldehyde N,N-dialkylhydrazones to simple aldehydes takes place in the presence of ZnCl2 or Et2AlCl to afford the corresponding α-hydroxyhydrazones. More reactive aldehydes undergo addition of these reagents in the absence of promoters. Use of (S)-1-methyleneamino-2-(diphenylmethoxymethyl) pyrrolidine as the reagent afforded separable mixtures of diastereoisomers, thereby allowing for the isolation of optically pure adducts in a single step.