60159-37-7

Basic information

• Product Name: 1-(4-chloropyridin-2-yl)ethanone
• Synonyms: 1-(4-chloropyridin-2-yl)ethanone;1-(4-Chloropyridine-2-yl)ethanone;2-Acetyl-4-chloropyridine;1-(4-chloropyridin-2-yl)ethan-1-one;1-(4-Chloro-2-pyridinyl)-ethanone;1-(4-Chloro-2-pyridyl)ethanone;1-(4-Chloropyridine-2-yl)
• CAS NO: 60159-37-7
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Mol File: 60159-37-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 238℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.233
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 1.06±0.10(Predicted)
• CAS DataBase Reference: 1-(4-chloropyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloropyridin-2-yl)ethanone(60159-37-7)
• EPA Substance Registry System: 1-(4-chloropyridin-2-yl)ethanone(60159-37-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 60159-37-7(Hazardous Substances Data)

Usage

Uses

1-(4-Chloropyridin-2-yl)ethanone is a useful reagent for the asymmetric synthesis of pyridylalkylamines.

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 1278596-23-8 C₂₂H₂₂BF₄N₃O₃ 
• 1278596-21-6 C₁₅H₈ClF₄N₃O 
• 1278596-20-5 C₁₅H₁₀ClF₄N₃O₂ 
• 1278596-19-2 C₂₀H₁₉ClN₄O 
• 1278596-17-0 C₁₈H₁₅ClN₄O 

Relevant articles and documents

COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

PYRIDINYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF PI3 KINASES

Compounds of the formula (I), in which X1, X2, L, Y, R2, R3, R4, R5, R6, R7, R8, R9, R10 have the meanings indicated in claim 1, are PI3K inhibitors and can be employed, inter alia, for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumours.

Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives

Chiral 4-(N,N-dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of a family of 4-chloro-2-(1-hydroxyalkyl)pyridines is the key step for the formation of potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in the acylation of the (R)-enantiomers (E > 200) using vinyl acetate as acylating agent and THF as solvent, obtaining products and substrates enantiomerically pure and with excellent yields.