60207-89-8Relevant articles and documents
Process for synthesizing propiconazole
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Paragraph 0027-0032, (2021/09/29)
The invention discloses a process method for synthesizing propiconazole. To 2, 4 -dichloro acetophenone serves as a starting raw material, and cyclization, bromination and condensation to prepare propiconazole comprises the following steps: 2, 4 -dichloro acetophenone and 1, 2 - pentanediol in a solvent benzene, cyclization reaction is carried out under the action of a catalyst to obtain a cyclized product. A bromide is obtained by brominating the cyclized product with bromine. The bromide, triazole in the solvent are subjected to a condensation reaction under the action of a base and a phase transfer catalyst to obtain propiconazole. The method is mild in reaction condition, simple and convenient to operate, capable of avoiding the generation of propiconazole isomer, improving the purity of propiconazole, high in reaction yield, reduced by-products and reduced in production cost.