602319-12-0Relevant articles and documents
A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: Design and synthesis of isotaxel
Hayashi, Yoshio,Skwarczynski, Mariusz,Hamada, Yoshio,Sohma, Youhei,Kimura, Tooru,Kiso, Yoshiaki
, p. 3782 - 3784 (2007/10/03)
A novel water-soluble paclitaxel prodrug, isotaxel 2, that realizes a higher water-solubility and the formation of paclitaxel through a simple pH-dependent chemical mechanism via the O-N acyl migration was synthesized and showed promising results in water