6024-85-7

Basic information

• Product Name: TETRAHYDROPALMATINE HYDROCHLORIDE
• Synonyms: (D,L)-TETRAHYDROPALMATINE HYDROCHLORIDE;TETRAHYDROPALMATINE HYDROCHLORIDE;SALOR-INT L202088-1EA;2,3,9,10-tetramethoxy-,hydrochloride,(+-)-berbin;tetrahydro-,hydrochloride,(+-)-palmatin;Tetrahydropalmatine, HCl;corydalis B;Tetrahydropalmatine Sulfate 10097-84-4 /
• CAS NO: 6024-85-7
• Molecular Formula: C21H26ClNO4
• Molecular Weight: 391.89
• Product Categories: Natural Plant Extract;Inhibitors
• Mol File: 6024-85-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 222-223 °C (decomp)
• Boiling Point: 482.9 °C at 760 mmHg
• Flash Point: 138.7 °C
• Appearance: solid
• Vapor Pressure: 1.76E-09mmHg at 25°C
• CAS DataBase Reference: TETRAHYDROPALMATINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROPALMATINE HYDROCHLORIDE(6024-85-7)
• EPA Substance Registry System: TETRAHYDROPALMATINE HYDROCHLORIDE(6024-85-7)

Safety Data

• Hazardous Substances Data: 6024-85-7(Hazardous Substances Data)

Usage

Uses

Hydrochloride salt of DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

InChI:InChI=1/C21H25NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,10-11,17H,7-9,12H2,1-4H3;1H

Upstream product

• 483-14-7 tetrahydropalmatine 

Relevant articles and documents

Bioactive isoquinoline alkaloids from Corydalis saxicola

Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)-2,9-dihydroxyl-3,11-dimethoxy-1,10- dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC 50 values of less than 10M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.