60251-90-3

Basic information

• Product Name: Propanoic acid, 2-(4-fluorophenoxy)-, (R)-
• CAS NO: 60251-90-3
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.167
• Mol File: 60251-90-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(4-fluorophenoxy)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(4-fluorophenoxy)-, (R)-(60251-90-3)
• EPA Substance Registry System: Propanoic acid, 2-(4-fluorophenoxy)-, (R)-(60251-90-3)

Safety Data

• Hazardous Substances Data: 60251-90-3(Hazardous Substances Data)

Upstream product

• 103196-99-2 (R)-ethyl 2-(4-fluorophenoxy)propionate 
• 371-41-5 4-Fluorophenol 
• 2967-70-6 2-(p-fluorophenoxy)propionic acid 
• 143094-69-3 methyl (+/-)-2-(4-fluorophenoxy)propanoate 
• 394646-82-3 ethyl (+/-)-2-(4-fluorophenoxy)propanoate 

Relevant articles and documents

HPLC separation of 2-aryloxycarboxylic acid enantiomers on chiral stationary phases

The possibility for separating enantiomers of a number of practically significant 2-aryloxycarboxylic acids was studied by normal- and reversed-phase HPLC on popular chiral stationary phases. The best separation parameters were achieved on the chiral phases with the polysaccharide base Chiralcel OD-H and Chiralpack AD under the normal-phase HPLC conditions. The (S)- and (R)-enantiomers of 2-(1-naphthyloxy)- and 2-(2-iodophenoxy)propionic acids with enantiomeric excess ee >99% were isolated using preparative chiral HPLC.

Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column

A technique based on liquid chromatography has been developed to facilitate studies of enantioselectivity in penicillin G acylase (PGA)-catalyzed hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues. PGA was covalently immobilized on an aminopropyl monolithic silica support to create an immobilized HPLC-enzyme reactor. Two sets of experimental data were drawn to calculate the enantioselectivity (E) of the kinetically controlled enantiomer-differentiating reaction, the degree of substrate conversion and the enantiomeric excess of the product. The developed enzymatic reactor was coupled through a switching valve to an achiral analytical column for separation and quantitation of the hydrolysis products. The enantiomeric excess was determined off-line on a PGA-chiral stationary phase. In this way, highly precise E values were determined. A computational study related to the hydrolysis of the considered racemic esters was also carried out in order to unambiguously clarify both the substrate specificity and the enantioselectivity displayed by PGA.

Fluorinated Lactic Acids: Easily Accessible Reagents for the Analysis of Chiral Compounds by (19)F NMR Spectroscopy. (19)F NMR Separation of the Eight Isomers of Menthol

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