60254-95-7 Usage
Description
5-Hydroxymebendazole, a metabolite of Mebendazole, belongs to the Benzimidazole class of compounds. These compounds are recognized for their safe and broad-spectrum anthelmintic properties, making them a popular choice for the prevention and treatment of parasitic infections in food-producing animals. As a white to off-white solid, 5-hydroxymebendazole contributes to the effectiveness of Benzimidazoles in combating various parasites.
Uses
Used in Veterinary Medicine:
5-Hydroxymebendazole is used as an anthelmintic agent for the prevention and treatment of parasitic infections in food-producing animals. Its application helps to control and eliminate harmful parasites, ensuring the health and productivity of livestock.
Used in Parasite Control:
5-Hydroxymebendazole serves as a key component in parasite control strategies, targeting a wide range of parasites that can cause significant health issues and reduce the overall productivity of animals in the food industry.
Used in Research and Development:
As a metabolite of Mebendazole, 5-hydroxymebendazole is also utilized in research and development efforts to better understand the mechanisms of Benzimidazoles and their potential applications in various fields, including pharmaceuticals and agriculture.
Check Digit Verification of cas no
The CAS Registry Mumber 60254-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,5 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60254-95:
(7*6)+(6*0)+(5*2)+(4*5)+(3*4)+(2*9)+(1*5)=107
107 % 10 = 7
So 60254-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9,14,20H,1H3,(H2,17,18,19,21)
60254-95-7Relevant articles and documents
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1
Zhang, Zhongsheng,Ojo, Kayode K.,Johnson, Steven M.,Larson, Eric T.,He, Penqing,Geiger, Jennifer A.,Castellanos-Gonzalez, Alejandro,White Jr., A. Clinton,Parsons, Marilyn,Merritt, Ethan A.,Maly, Dustin J.,Verlinde, Christophe L.M.J.,Van Voorhis, Wesley C.,Fan, Erkang
scheme or table, p. 5264 - 5267 (2012/09/07)
Calcium-dependent protein kinase-1 (CDPK1) from Cryptosporidium parvum (CpCDPK1) and Toxoplasma gondii (TgCDPK1) have become attractive targets for discovering selective inhibitors to combat infections caused by these protozoa. We used structure-based design to improve a series of benzoylbenzimidazole-based compounds in terms of solubility, selectivity, and potency against CpCDPK1 and TgCDPK1. The best inhibitors show inhibitory potencies below 50 nM and selectivity well above 200-fold over two human kinases with small gatekeeper residues.
