6027-23-2Relevant articles and documents
Preparation method of hordenine hydrochloride
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Paragraph 0042-0045, (2021/11/10)
The invention discloses a preparation method of hordenine hydrochloride. The preparation method comprises the following steps: taking 4-(2-bromoethyl)phenol as a raw material, adding ethanol to prepare a solution, dropwise adding excessive dimethylamine solution, and stirring at a lower temperature to carry out amination reaction to obtain hordenine hydrobromide. The proper excessive dimethylamine is adopted, so that the quaternization side reaction is effectively inhibited, the solvent dispersion effect is also played, the contact reaction opportunity of the hordenine product generated in the first reaction and the 4-(2-bromoethyl)phenol added later is greatly reduced, the high product yield can be kept, and meanwhile the low preparation cost is achieved; 4-(2-bromoethyl) phenol is added into ethanol to prepare a dilute solution of ethanol, and the dilute solution of ethanol is dropwise added into a dimethylamine solution to improve the dispersity of 4-(2-bromoethyl) phenol in a reaction system and inhibit quaternization side reaction; and the amination reaction is carried out by stirring at a relatively low temperature of 10-25 DEG C, so that the occurrence of quaternization side reaction is inhibited, and a relatively good reaction effect is achieved.
THE BIOSYNTHESIS OF SCELETIUM ALKALOIDS IN SCELETIUM SUBVELUTINUM
Herbert, Richard B.,Kattah, Abdullah E.
, p. 141 - 144 (2007/10/02)
Six Sceletium (Mesembrine) alkaloids (1)-(6) are identified, together with N,N-dimethyltyramine (10) as constituents of Sceletium subvelutinum.The alkaloids (1)-(6) incorporate label from radioactive tyramine (8) and 4-hydroxyphenylpropionic acid (12) as expected; notably -4-hydroxydihydrocinnamaldehyde is a more efficient alkaloid precursor than the acid (12).Preliminary evidence locates the amine (16) potentially as a key precursor for Sceletium alkaloids; (14) is less efficiently incorporated.