60398-41-6

Basic information

• Product Name: Boc-L-Phe-CHN2
• Synonyms: BOC-L-PHE-CHN2;(S)-tert-butyl (4-diazo-3-oxo-1-phenylbutan-2-yl)carbamate(WXG00296);(S)-tert-butyl (4-diazo-3-oxo-1-phenylbutan-2-yl)carbamate
• CAS NO: 60398-41-6
• Molecular Formula: C₁₅H₁₉N₃O₃
• Molecular Weight: 0
• Mol File: 60398-41-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Boc-L-Phe-CHN2(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Phe-CHN2(60398-41-6)
• EPA Substance Registry System: Boc-L-Phe-CHN2(60398-41-6)

Safety Data

• Hazardous Substances Data: 60398-41-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 541-41-3 chloroformic acid ethyl ester 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 543-27-1 isobutyl chloroformate 
• 33294-54-1 N-t-butoxycarbonyl-L-phenylalanine anhydride 
• 70-25-7 N-Methyl-N'-nitro-N-nitrosoguanidine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 462101-51-5 ((S)-1-Chlorocarbonyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 67729-36-6 Boc-Phe-O-COO-isoBu 

Downstream Products

• 170116-28-6 N-tert-butyloxycarbonyl-(S)-β³-homophenylalanyl-N-methylamide 
• 60398-42-7 methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate 
• 1251537-74-2 C₁₈H₂₅NO₄ 
• 118457-05-9 Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate 
• 1027306-89-3 ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester 
• 1026473-02-8 {(S)-5-[(S)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-4-phenyl-butylamino)-3-phenyl-propionylamino]-5-carbamoyl-pentyl}-carbamic acid benzyl ester 
• 267007-65-8 Boc-N-Me-β³-HPhe-N-Me-β³-HTrp(OBn)-β³-HLys(N^ε-2-Cl-Z)-OMe 
• 267007-62-5 (3S)-3-{[(tert-butoxy)carbonyl](methyl)amino}-4-phenylbutanoic acid 

Relevant articles and documents

Design and Optimization of a Continuous Stirred Tank Reactor Cascade for Membrane-Based Diazomethane Production: Synthesis of α-Chloroketones

The development of a continuous diazomethane generator comprising a continuous stirred tank reactor (CSTR) cascade and membrane separation technology is reported. This reactor concept was applied for the telescoped three-step synthesis of a chiral α-chloroketone, a key building block for many HIV protease inhibitors, via a modified Arndt-Eistert reaction starting from N-protected l-phenylalanine. The initial mixed anhydride was generated in a coil reactor and directly introduced into the CSTR diazomethane cascade. The use of a semipermeable Teflon membrane (AF-2400) allowed the generation of anhydrous diazomethane, which diffuses through the membrane into the CSTR where it is immediately consumed by the anhydride to furnish the corresponding diazoketone. The subsequent halogenation with concentrated HCl was performed downstream in batch and allowed production of the α-chloroketone on a multigram scale, with a productivity of 1.54 g/h (5.2 mmol/h).

METHOD FOR THE PREPARATION OF DIAZOALKANES

The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used.

One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using Nα-amino selenocarboxamides and α-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized.