6040-06-8Relevant articles and documents
Vanillylamine type new compound as well as preparation method and medical appliance thereof
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, (2016/10/31)
The invention provides a novel compound of a treatment medicine or preventive medicine serving as an analgesic drug, and a medicinal composition containing the same. The invention relates to a vanillylamine type new compound or a pharmaceutically acceptab
2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization
Cermak, Diana M.,Wiemer, David F.,Lewis, Kriste,Hohl, Raymond J.
, p. 2729 - 2737 (2007/10/03)
2-(Acyloxy)ethylphosphonate analogues of geranyl, farnesyl, and geranylgeranyl pyrophosphate have been prepared. Horner-Wadsworth-Emmons condensation of different terpene aldehydes with an unsymmetrical bisphosphonate was the key step in syntheses of the phosphonates bearing α,β-unsaturated acyloxy groups. After preparation of the respective phosphonic acids through reaction with TMSBr, both acids and esters were tested for their effects on DNA synthesis in human-derived myeloid and lymphoid leukemia cell lines. The phosphonate esters varied substantially in their ability to impair proliferation of the different cell lines, but testing against one possible target, farnesyl protein transferase (FPTase), revealed little impact at concentrations ranging up to 10μM. Because the corresponding 2,3-dihydro compounds showed similar biological activity, conjugate addition would not appear to be involved in the toxicity. Copyright (C) 2000 Elsevier Science Ltd.
Process for preparing stereospecific nerolidol and ester thereof
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, (2008/06/13)
A process for obtaining a stereospecific nerolidol at the Δ6 -position thereof by rectifying a mixture of Δ6 -cis-nerolidol and Δ6 -trans-nerolidol in rectification column having from 10 to 100 theoretical plates with a reflux ratio of from 2 to 200 at a temperature below 230° C. under reduced pressure to separate each stereospecific nerolidol from said mixture.
