6045-53-0 Usage
Description
Estra-1,3,5(10)-triene-3,17alpha-diol 3-benzoate, also known as α-Estradiol 3-Benzoate, is a derivative of 17α-Estradiol (E887995), a biologically active estrogen. It plays a significant role in human breast cancer cells in tissue culture and is involved in a system with important autocrine/paracrine functions in the developing and adult brain.
Uses
Used in Pharmaceutical Industry:
Estra-1,3,5(10)-triene-3,17alpha-diol 3-benzoate is used as a pharmaceutical compound for its estrogenic properties. It is particularly relevant in the treatment and study of breast cancer cells, as it interacts with the biologically active estrogen in these cells.
Used in Research Applications:
In the field of research, estra-1,3,5(10)-triene-3,17alpha-diol 3-benzoate is used as a research tool to study the effects of estrogen on various cellular processes and its role in the development and functioning of the brain. This helps in understanding the autocrine/paracrine functions of the 17-Estradiol and its selective receptor, ER-X.
Used in Drug Development:
Estra-1,3,5(10)-triene-3,17alpha-diol 3-benzoate is also utilized in the development of new drugs targeting estrogen-responsive conditions, such as certain types of cancer and other hormone-related disorders. Its understanding of the molecular mechanisms involved in these conditions can lead to the creation of more effective and targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 6045-53-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,4 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6045-53:
(6*6)+(5*0)+(4*4)+(3*5)+(2*5)+(1*3)=80
80 % 10 = 0
So 6045-53-0 is a valid CAS Registry Number.
6045-53-0Relevant articles and documents
Perfluoroalkylsulfonyl fluoride in organic synthesis: a facile synthesis of 17α-hydroxy steroids
Guo, Peng-Peng,Ding, Kai
, p. 4096 - 4100 (2015/08/03)
Abstract A facile synthesis of 17α-hydroxy steroids with perfluoroalkylsulfonyl fluoride as hydroxyl activating agent was reported. The method features mild (40 °C), rapid (0.5 h), high yield, and high functional group tolerance. Notably, the method is applicable to HCOOH and CF3COOH, unusual and synthetically useful nucleophiles in hydroxyl inversion reaction.
