60472-19-7

Basic information

• Product Name: 5-(4-BroMophenyl)-1H-iMidazol-2-aMine
• Synonyms: 4-(4-Bromo-phenyl)-1H-imidazol-2-ylamine;5-(4-BroMophenyl)-1H-iMidazol-2-aMine;4-(4-BroMophenyl)-1H-iMidazol-2-aMine
• CAS NO: 60472-19-7
• Molecular Formula: C₉H₈BrN₃
• Molecular Weight: 238.08392
• Mol File: 60472-19-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-BroMophenyl)-1H-iMidazol-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BroMophenyl)-1H-iMidazol-2-aMine(60472-19-7)
• EPA Substance Registry System: 5-(4-BroMophenyl)-1H-iMidazol-2-aMine(60472-19-7)

Safety Data

• Hazardous Substances Data: 60472-19-7(Hazardous Substances Data)

Usage

Class

Imidazole derivatives

Molecular weight

244.08 g/mol

Functional groups

Bromine substituent on the phenyl ring, amine group attached to the imidazole ring

Applications

Pharmaceutical research, drug development

Pharmacological properties

Ability to affect certain receptors in the body

Potential uses

Treatment of various diseases and disorders

Role

Valuable building block for synthesis of new pharmaceutical compounds

Upstream product

• 56921-85-8 2-(4-bromophenyl)imidazo[1,2-a]pyrimidine 
• 99-73-0 para-bromophenacyl bromide 
• 5699-40-1 acetylguanidine 

Downstream Products

• 1449518-31-3 2-((2-amino-5-(4-bromophenyl)-1H-imidazol-4-yl)(p-tolyl)methyl)-3-hydroxy-5,5-dimethylcyclohex-2-enone 
• 1292220-33-7 {4-[2-(4-bromo-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-6-yl]-benzyl}-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis, Molecular Properties Prediction and Antimicrobial Activity of Imidazolyl Schiff Bases, Triazoles and Azetidinones

Benzylidenehydrazinyl imidazoles (3) are prepared from 2-hydrazinyl imidazoles (2) on treatment with hydrazine. The imine functionality in 3 is utilized to develop 5′-aryl-N-(4-aryl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-amines (5) by 1,3-dipolar cycloaddition of diazomethane followed by aromatization with I2 in DMSO. Compounds 3 are also explored to prepare 4′-aryl-1-(4-aryl-1H-imidazol-2-ylamino)-3-chloroazetidin-2-ones (6) on treatment with chloroacetyl chloride. The Molinspiration calculations predicted that 3, 5 and 6 have molecular hydrophobicity, conformational flexibility, good intestinal absorption and bioactivity scores. The chloro, bromo and nitro substituted imidazolyl azetidinones (6c, 6d, 6f) and nitro substituted imidazolyl triazole (5f) exhibited excellent antibacterial activity on B. subtilis, whereas chloro and nitro substituted imidazolyl triazoles (5c, 5f) showed prominent antifungal activity on A. niger.

Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes

A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5-chlorothiophene-2-carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.

COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS

This invention relates to substituted 2-aminoimidazoles and their imidazo[1,2- a]pyrimidinium salts precursors being active against biofilm formation. The present invention also relates to antimicrobial compositions comprising a microbial biofilm formatio