60481-51-8

Basic information

• Product Name: 3,4-Dimethylphenylhydrazine hydrochloride
• Synonyms: LABOTEST-BB LT01148173;3,4-DIMETHYLPHENYLHYDRAZINE HCL;1-(3,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE;3,4-DIMETHYLPHENYLHYDRAZINE HYDROCHLORID;3,4-Dimethylphenylhydrazine hydrochloride,98%;3,4-Dimethylphenylhydrazine hydrochloride;3,4-DIMETHYLPHENYLHYDRAZINE HYDOCHLORIDE;4-Hydrazino-o-xylene hydrochloride
• CAS NO: 60481-51-8
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.66
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;API intermediates;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 60481-51-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 195-200 °C(lit.)
• Boiling Point: 252.2oC at 760 mmHg
• Flash Point: 122.2oC
• Appearance: White to pink or beige-brown powder
• Density: 1.058g/cm³
• Vapor Pressure: 0.0196mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble in water.
• BRN: 6096060
• CAS DataBase Reference: 3,4-Dimethylphenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethylphenylhydrazine hydrochloride(60481-51-8)
• EPA Substance Registry System: 3,4-Dimethylphenylhydrazine hydrochloride(60481-51-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 60481-51-8(Hazardous Substances Data)

Usage

Description

3,4-Dimethylphenylhydrazine hydrochloride is an organic compound with the chemical formula C8H12N2·HCl. It is a white to pink or beige-brown powder and is commonly used as a reactant in the synthesis of various organic compounds.

Uses

Used in Chemical Synthesis:
3,4-Dimethylphenylhydrazine hydrochloride is used as a reactant for the production of 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction requires the use of reagent K2CO3 and the menstruum ethanol.
In the pharmaceutical industry, 3,4-Dimethylphenylhydrazine hydrochloride can be used as a building block for the synthesis of various pharmaceutical compounds due to its reactive nature and the presence of the hydrazine functional group.
Additionally, it may be utilized in the research and development of new chemical entities, particularly in the fields of organic chemistry and medicinal chemistry, where its unique structural features can be exploited to create novel molecules with potential applications in various industries.

InChI:InChI=1/C8H12N2/c1-6-3-4-8(10-9)5-7(6)2/h3-5,10H,9H2,1-2H3

Upstream product

• 583-71-1 4-bromo-o-xylene 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 1083098-22-9 4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1-(3,4-dimethylphenyl)-1,2-dihydro-3H-pyrazol-3-one 
• 38829-72-0 5,6-dimethyl-2,3-diphenyl-1H-indole 
• 374924-94-4 acetic acid N'-(3,4-dimethylphenyl)hydrazide 
• 277299-70-4 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 374924-93-3 2-(3,4-dimethylphenyl)-2,4-dihydropyrazol-3-one 

Relevant articles and documents

Method for synthesizing eltrombopag by using micro-channel reactor

The invention discloses a method for synthesizing eltrombopag by using a micro-channel reactor. The method comprises the following steps: S1, material synthesis: adding a raw material 3, 4-dimethylaniline into an acid aqueous solution, dissolving to obtain a material I, dissolving sodium nitrite into water to obtain a material II, dissolving sodium hydrogen sulfite and sodium hydroxide into water to obtain a material III, taking a solution prepared from hydrochloric acid and water as a material IV, adding a raw material 3-amino-2 hydroxyl-[1, 1-biphenyl]-3 formic acid into the acid aqueous solution, dissolving to obtain a material V, and dissolving sodium nitrite into water to obtain a material VI; s2, introducing the material into the micro-channel reactor S3 to obtain a first intermediate 3, 4-dimethylphenylhydrazine hydrochloride, and reacting with ethyl acetoacetate to obtain a second intermediate 2-(3, 4-dimethylphenyl)-5-methyl-1H-pyrazole-3 (2H)-ketone; and S4, introducing the material V and the material VI into the micro-channel reactor for reaction, and enabling the effluent reaction liquid to directly flow into a reaction bottle filled with a 2-(3, 4-dimethylphenyl)-5-methyl-1H-pyrazole-3 (2H)-ketone solution, thereby obtaining eltrombopag.

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

Facile and convenient synthesis of aryl hydrazines via copper-catalyzed C-N cross-coupling of aryl halides and hydrazine hydrate

An efficient and convenient method for the synthesis of aryl hydrazines has been developed via copper-catalyzed cross-coupling of aryl bromides and hydrazine with a readily accessible ligand and water as a solvent. The multigram scale procedure is applicable to aryl bromides bearing both moderately electron-donating and electron-withdrawing substituents in the aromatic nucleus. No column chromatography is required to obtain aryl hydrazine hydrochlorides in good yields.