60538-15-0

Basic information

• Product Name: H-D-THR-OME HCL
• Synonyms: D-Thr-OMe·HCl;H-D-THR-OME HCL;D-THREONINE METHYL ESTER HYDROCHLORIDE;D-THREONINE-OME HCL;D-Threonine Methyl Ester HCl;H-D-Thr-OMe;Methyl D-threoninate hydrochloride;(2R,3S)-Methyl2-aMino-3-hydroxybutanoatehydrochloride
• CAS NO: 60538-15-0
• Molecular Formula: C₅H₁₁NO₃*ClH
• Molecular Weight: 169.61
• Product Categories: Amino Acids and Derivatives;Amino hydrochloride
• Mol File: 60538-15-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 159-162℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-D-THR-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-THR-OME HCL(60538-15-0)
• EPA Substance Registry System: H-D-THR-OME HCL(60538-15-0)

Safety Data

• Hazardous Substances Data: 60538-15-0(Hazardous Substances Data)

Usage

Uses

D-Threonine methyl ester is a protected form of D-Threonine (T405525). D-Threonine is the unnatural isomer of L-Threonine (T405500) and is known to inhibit growth and cell wall synthesis of Mycobacterium smegmatis. D-Threonine is also used as a synthetic intermediate for the production of chiral antibiotics.

Upstream product

• 67-56-1 methanol 
• 72-19-5 L-threonine 
• 72-19-5 DL-threonine 
• 28954-12-3 (2S,3S)-2-amino-3-hydroxybutanoic acid 
• 60143-52-4 DL-aThr*HCl 
• 72-19-5 rac-allo-threonine 
• 60143-52-4 DL-threonine hydrochloride 
• 72-19-5 D-threonine 
• 1487-49-6 3-hydroxybutyric acid methyl ester 

Downstream Products

• 85482-79-7 N-trityl-D-threonine methyl ester 
• 17554-22-2 CBZ-Phe-Thr-OMe 
• 182267-22-7 C₆H₉NO₄ 

Relevant articles and documents

(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative as well as preparation method and application thereof

The invention discloses a (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative shown as a formula (I) or an optical isomer, a diastereomer and racemate mixture and pharmaceutically acceptable salt thereof as well as a preparation method and application of the (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative. It is shown by comparison of results of a positive control group and a model group on lymphedema prevention experiments that the compound disclosed in the invention shows obvious anti-edema activity.

Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal

Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S, N -heterocycles are more stable than the corresponding O, N -heterocycles but both are synthetic intermediates capable of further elaboration.

Singlet Oxygen Photooxidation of Peptidic Oxazoles and Thiazoles

Oxazoles and thiazoles are commonly found moieties in nonribosomal peptides (NRPs) and ribosomally synthesized post-translationally modified peptides (RiPPs), which are important biomolecules present in the environment and in natural waters. From previous studies, they seem susceptible to oxidation by singlet oxygen (1O2); therefore, we designed and synthesized model oxazole- and thiazole-peptides and measured their1O2 bimolecular reaction rate constants, showing slow photooxidation under environmental conditions. We reasoned their stability through the electron-withdrawing effect of the carboxamide substituent. Reaction products were elucidated and support a reaction mechanism involving cycloaddition followed by a series of rearrangements. The first1O2 bimolecular reaction rate constant for a RiPP, the thiazole-containing peptide Aerucyclamide A, was measured and found in good agreement with the model peptide's rate constant, highlighting the potential of using model peptides to study the transformations of other environmentally relevant NRPs and RiPPs.