6055-19-2 Usage
Description
Cyclophosphamide monohydrate is a fine white crystalline powder with a slightly bitter taste and little or no odor. It is the monohydrate form of cyclophosphamide, a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. Cyclophosphamide monohydrate is known for its ability to cross-link DNA, cause strand breakage, and induce mutations, which contribute to its effectiveness in treating various conditions.
Uses
1. Used in Cancer Chemotherapy:
Cyclophosphamide monohydrate is used as an antineoplastic and alkylating agent in cancer therapy. It is particularly effective against a range of cancers due to its ability to alkylate and damage DNA, leading to cell death. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
2. Used in Autoimmune Disorders:
Cyclophosphamide monohydrate is also used to treat autoimmune disorders. As an immunosuppressive agent, it helps to reduce the immune system's response, providing relief from the symptoms of these conditions.
3. Used in AL Amyloidosis Treatment:
Cyclophosphamide monohydrate is utilized in the treatment of AL amyloidosis, a rare condition where abnormal proteins build up in organs and tissues, causing damage and impairing their function.
4. Used in Cancer Research:
Cyclophosphamide monohydrate is involved in cancer research as a tool that induces apoptosis (programmed cell death) in tumor cells. This property makes it a valuable asset in the study of cancer biology and the development of new therapeutic strategies.
5. Used in Drug Development:
As a cytotoxic agent, cyclophosphamide monohydrate is also used in the development of new drugs and drug delivery systems, aiming to improve the treatment of various cancers and autoimmune disorders.
Air & Water Reactions
Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.
Reactivity Profile
Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.
Fire Hazard
Cyclophosphamide monohydrate is probably combustible.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Safety Profile
Confirmed human
carcinogen. Poison by ingestion and
intravenous routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Cl-, PO,, and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 6055-19-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,5 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6055-19:
(6*6)+(5*0)+(4*5)+(3*5)+(2*1)+(1*9)=82
82 % 10 = 2
So 6055-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2/t14-;/m1./s1
