60559-99-1

Basic information

• Product Name: 1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine
• Synonyms: guanidine, N-cyano-N''-(2,2-dimethylpropyl)-N'-3-pyridinyl-
• CAS NO: 60559-99-1
• Molecular Formula: C₁₂H₁₇N₅
• Molecular Weight: 231.2969
• Mol File: 60559-99-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 347.6°C at 760 mmHg
• Flash Point: 164.1°C
• Density: 1.07g/cm³
• Vapor Pressure: 5.31E-05mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine(60559-99-1)
• EPA Substance Registry System: 1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine(60559-99-1)

Safety Data

• Hazardous Substances Data: 60559-99-1(Hazardous Substances Data)

Usage

Molecular structure

1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine has a complex molecular structure, consisting of a guanidine derivative with a cyano group and a pyridin-3-yl moiety.

Classification

It is a chemical compound that falls under the category of guanidine derivatives.

Pharmaceutical research

The compound is used in pharmaceutical research, being studied for its potential medicinal properties.

Potential applications

It may have applications in the treatment of various diseases and conditions, but further research is needed to fully understand its potential uses and effects.

Specific properties and mechanisms

The compound's specific properties and mechanisms of action are not fully known.

Safety and effectiveness

Further research is necessary to determine the safety and effectiveness of 1-cyano-2-(2,2-dimethylpropyl)-3-pyridin-3-ylguanidine for medicinal purposes.

Upstream product

• 17452-27-6 pyridin-3-yl isothiocyanate 
• 60560-51-2 1-(2,2-dimethyl-propyl)-3-pyridin-3-yl-thiourea 
• 5813-64-9 2.2-dimethylpropylamine 
• 420-04-2 CYANAMID 
• 60572-88-5 (2,2-Dimethyl-propyl)-pyridin-3-yl-carbodiimide 

Relevant articles and documents

Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas

Potassium channel opening activity for pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas, has been assessed through simultaneous measurement of spontaneous contractile activity and stimulation of 86Rb+ efflux from rat portal veins loaded with 86Rb+. The good correlation between these two effects suggests that the vasodilator activity of the compounds is directly attributable to an increased opening of potassium channels. The resulting quantitative in vitro data has been used to analyze the structure-activity relationships for potassium channel opening, allowing the biological activity to be rationalized in terms of a pharmacophore involving a hydrogen-bond-acceptor element, a hydrogen-bond- donor element, and a lipophilic binding group. A model for the binding of pinacidil-related compounds to their potassium channel receptor has been developed, and compounds designed to test this model have been synthesized and tested. Prototropic equilibria are implicated as playing a fundamental role in determining the hydrogen-bonding ability of the compounds, and conformational changes in the receptor are invoked to explain disparities in the chiral recognition of lipophilic groups in different compounds.