6057-60-9

Basic information

• Product Name: 4-(4-BIPHENYLYL)BUTYRIC ACID
• Synonyms: 4-(4-BIPHENYLYL)BUTYRIC ACID;4-(Biphenyl-4-yl)butanoic acid;4-Phenylbenzenebutanoic acid;γ-(4-Biphenylyl)butyric acid;4-biphenyl-4-yl-butyric acid;4-([1,1'-Biphenyl]-4-yl)butanoic acid
• CAS NO: 6057-60-9
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 6057-60-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 119.5°C
• Boiling Point: 343.02°C (rough estimate)
• Flash Point: 311.122 °C
• Appearance: /
• Density: 1.0752 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6290 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-BIPHENYLYL)BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BIPHENYLYL)BUTYRIC ACID(6057-60-9)
• EPA Substance Registry System: 4-(4-BIPHENYLYL)BUTYRIC ACID(6057-60-9)

Safety Data

• Hazardous Substances Data: 6057-60-9(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the acid from MeOH (m 118o) or *C6H6 (m 118-119o). [Beilstein 9 I 290, 9 III 3370, 9 IV 2558.]

InChI:InChI=1/C16H16O2/c17-16(18)8-4-5-13-9-11-15(12-10-13)14-6-2-1-3-7-14/h1-3,6-7,9-12H,4-5,8H2,(H,17,18)

Upstream product

• 92-52-4 biphenyl 
• 20120-35-8 4-allylbiphenyl 
• 124-38-9 carbon dioxide 
• 61221-46-3 1-p-biphenylyl-3-chloropropane 

Downstream Products

• 36330-85-5 3-(p-phenyl)benzoylpropionic acid 
• 1391735-27-5 MRJ₁₆ 
• 1391735-35-5 MRJ₁₄ 
• 41526-73-2 7-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 5449-41-2 2-biphenyl-4-yl-valeric acid 
• 37949-65-8 5-p-Biphenylyl-2,2-diphenylpentansaeure 
• 54796-09-7 4-p-Biphenylyl-1,1-diphenylbutyl-methylether 
• 37949-66-9 4-p-Biphenylyl-1,1-diphenylbutan 
• 37949-70-5 8-Phenylspiro-<4,5>-6,9-decadien-8-carbonsaeure 
• 51994-31-1 5-(1,1'-biphenyl-4-yl)pentanoic acid 
• 34874-54-9 4-(biphenyl-4-yl)butanol 
• 37949-71-6 γ-Phenylspiro<4.5>deca-6.9-dien 
• 17098-76-9 1-(1-Butyl)-4-cyclohexylbenzol 
• 796-37-2 1,7-Diphenyl-3,4-dihydro-naphthalin 

Relevant articles and documents

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Carbanions. 21. Reactions of 2- and 3-p-Biphenylylalkyl Chlorides with Alkali Metals. Preparation of Labile Spiro Anions

The present work was undertaken to see if (3-p-biphenylylpropyl)- and (2-p-biphenylethyl)cesium cyclize like (4-p-biphenylbutyl)cesium to stable spiro anions.Reaction of 1-p-biphenylyl-3-chloropropane (5) with Cs-K-Na alloy in THF at -75 deg C gave, under the optimum conditions found, 36percent of 7-phenylspironona-6,5-dien-5-yl anion (8) besides 3-p-biphenylylpropyl (7), 1-p-biphenylylpropyl (9), and p-biphenylylmethyl (10) anions, according to the products of carbonation.The spiro anion 8 (Cs+ as the counterion) has a half-life of about 13 min at -75 deg C.Incontrast, 5 reacts with lithium to give predominantly (3-p-biphenylylpropyl)lithium.Reaction of 1-p-biphenylyl-2-chloroethane with Cs-K-Na alloy gave no appreciable spiro anion under conditions which were successful with 5.In the reaction of 1-p-biphenylyl-2-chloro-2-methylpropane (28) with Cs-K-Na alloy the α-gem-dimethyl group accelerates migration of the p-biphenylyl group to give products similar to those from 2-p-biphenylyl-1-chloro-2-methylpropane (24); however, the expected intermediate spiro anion 26 was undetectable by the carbonation technique.With both α- and β-gem-dimethyl groups, 2-p-biphenylyl-3-chloro-2,3-dimethylbutane (41) reacts with Cs-K-Na alloy to give 1,1,2,2-tetramethyl-6-phenylspiroocta-5,7-dien-4-yl anion (43) and 2-p-biphenylyl-1,1,2-trimethylpropyl anion (42) in about a 2:1 ratio according to the results of carbonation.The open anion 42 and the spiro anion 43 appear to be in mobile equilibrium (Cs+ as the counterion) with half-lives of about 22 min in THF at -75 deg C.With lithium as counterion, only the open product (2-p-biphenylyl-1,1,2-trimethylpropyl)lithium (50) was detectable by carbonation.