60586-80-3Relevant articles and documents
Semiconductor-photocatalyzed sulfoxidation of alkanes
Parrino, Francesco,Ramakrishnan, Ayyappan,Kisch, Horst
, p. 7107 - 7109 (2008)
(Equation Presented) The C-H activation of alkanes with visible light is possible with a semiconductor as the photocatalyst. Upon irradiation, a mixture of titanium dioxide, sulfur dioxide, and oxygen can be used to convert alkanes into the corresponding sulfonic acids (see scheme).
Foldamers as reactive sieves: Reactivity as a probe of conformational flexibility
Smaldone, Ronald A.,Moore, Jeffrey S.
, p. 5444 - 5450 (2008/02/04)
A series of m-phenyleneethynylene (mPE) oligomers modified with a dimethylaminopyridine (DMAP) unit were treated with methyl sulfonates of varying sizes and shapes, and the relative reactivities were measured by UV spectrophotometry. Using a small-molecule DMAP analogue as a reference, each of the methyl sulfonates was shown to react at nearly identical rate. In great contrast, oligomers that are long enough to fold, and hence capable of binding the methyl sulfonate, experience rate enhancements of 18-1600-fold relative to that of the small-molecule analogue, depending on the type of alkyl chain attached to the guest. Three different oligomer lengths were studied, with the longest oligomers exhibiting the fastest rate and greatest substrate specificity. Even large, bulky guests show slightly enhanced methylation rates compared to that with the reference DMAP, which suggests a dynamic nature to the oligomer's binding cavity. Several mechanistic models to describe this behavior are discussed.
7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease
-
, (2008/06/13)
7-Oxabicycloheptane substituted interphenylene prostaglandin ethers are provided having the structural formula STR1 and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.