606143-29-7

Basic information

• Product Name: (2'S)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2,5-dione
• Synonyms: (2'S)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2,5-dione
• CAS NO: 606143-29-7
• Molecular Weight: 212.249
• Mol File: 606143-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2'S)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2'S)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2,5-dione(606143-29-7)
• EPA Substance Registry System: (2'S)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2,5-dione(606143-29-7)

Safety Data

• Hazardous Substances Data: 606143-29-7(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 

Downstream Products

• 606143-32-2 (E)-(2'S)-5-(4-methoxybenzylidene)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-37-7 (2'S,5S)-5-(4-methoxybenzyl)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-34-4 (E)-(2'S)-5-(4-fluorobenzylidene)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-39-9 (2'S,5S)-5-(4-fluorobenzyl)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-38-8 (2'S,5S)-5-(4-chlorobenzyl)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-33-3 (E)-(2'S)-5-(4-chlorobenzylidene)-2'-(methoxymethyl)[1,1']bipyrrolidinyl-2-one 
• 606143-31-1 (E)-(2'S)-2'-(methoxymethyl)-5-(4-methylbenzylidene)[1,1']bipyrrolidinyl-2-one 

Relevant articles and documents

Asymmetric synthesis of 5-arylmethylpyrrolidin-2-ones and 2-arylmethylpyrrolidines

An efficient methodology for the enantioselective synthesis of 5-arylmethylpyrrolidin-2-ones and 2-arylmethylpyrrolidines has been devised. The key step is the stereoselective hydrogenation of the N-acylhydrazonium salts obtained from the corresponding arylmethylene hydrazides. These highly conjugated compounds are readily prepared by reacting a chiral succinimide with a variety of arylmethyl Grignard reagents. Removal of the chiral auxiliary and subsequent reduction complete the synthesis of the title compounds.