60686-82-0

Basic information

• Product Name: (4R*,6R*)-2,2,6-Trimethyl-4-hydroxycyclohexan-1-one
• CAS NO: 60686-82-0
• Molecular Weight: 156.225
• Mol File: 60686-82-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (4R*,6R*)-2,2,6-Trimethyl-4-hydroxycyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R*,6R*)-2,2,6-Trimethyl-4-hydroxycyclohexan-1-one(60686-82-0)
• EPA Substance Registry System: (4R*,6R*)-2,2,6-Trimethyl-4-hydroxycyclohexan-1-one(60686-82-0)

Safety Data

• Hazardous Substances Data: 60686-82-0(Hazardous Substances Data)

Upstream product

• 60046-49-3 (6R)-levodione 
• 20547-99-3 2,6,6-trimethyl-1,4-cyclohexanedione 
• 1125-21-9 2,6,6-trimethyl-2-cyclohexene-1,4-dione 
• 100-99-2 triisobutylaluminum 

Downstream Products

• 94669-79-1 (1R,4R,6R)-1-((1E,3E)-5-Hydroxy-3-methyl-penta-1,3-dienyl)-2,2,6-trimethyl-cyclohexane-1,4-diol 
• 70905-68-9 (1S,4R,6R)-1-<(E)-5-hydroxy-3-methylpent-3-en-1-ynyl>-2,2,6-trimethylcyclohexane-1,4-diol 
• 91796-24-6 (1R,4R,6R)-1-<(E)-5-hydroxy-3-methylpent-3-en-1-ynyl>-2,2,6-trimethylcyclohexane-1,4-diol 
• 60686-81-9 (+)-(4R,6S)-4-hydroxy-2,2,6-trimethylcyclohexanone 
• 130583-95-8 (4R,6R)-4-[(tert-butyldimethylsilyl)oxy]-2,2,6-trimethylcyclohexan-1-one 
• 131134-43-5 (4R,6R)-2,2,6-Trimethyl-4-nitrosooxy-cyclohexanone 
• 72726-22-8 (+/-)-1-(2,6,6-trimethyl-4-hydroxycyclohexenyl)-1,3-butanedione 
• 82936-61-6 1-(2,6,6-trimethyl-1,4-dihydroxycyclohexyl)-1,3-butadiyne 
• 82936-61-6 1-(2,6,6-trimethyl-1,4-dihydroxycyclohexyl)-1,3-butadiyne 
• 98665-95-3 ethyl (1S,4R,6R)-4-hydroxy-1-(5-hydroxy-3-methyl-3E-penten-1-ynyl)-2,2,6-trimethylcyclohexylcarbonate 
• 130696-71-8 (1S,4R,6S)-1-<(E)-5-hydroxy-3-methylpent-3-en-1-ynyl>-2,2,6-trimethylcyclohexane-1,4-diol 
• 130696-72-9 (1R,4R,6S)-1-<(E)-5-hydroxy-3-methylpent-3-en-1-ynyl>-2,2,6-trimethylcyclohexane-1,4-diol 
• 121703-09-1 (4R,6R)-2,2,6-Trimethyl-4-(tetrahydro-pyran-2-yloxy)-cyclohexanone 
• 11048-74-1 (3R,3'R)-alloxanthin acetate 

Relevant articles and documents

On the bi-enzymatic behaviour of Saccharomyces cerevisiae-mediated stereoselective biotransformation of 2,6,6-trimethylcyclohex-2-ene-1,4-dione

Baker's yeast has been well-known to have the ability to reduce a variety of substrates into many optically active compounds. One of the important chemicals is (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone or in short, (4R,6R)-actinol, a product formed f

Synthesis of biotinylated retinoids for cross-linking and isolation of retinol binding proteins

The synthesis of (3R)-3-[Boc-Lys(biotinyl)-O]-11-cis-retinol bromoacetate and 3-[Boc-Lys(biotinyl)-O]-all trans-retinol chloroacetate is described. These biotinylated retinoids are instrumental in labeling the retinol binding proteins (RBPs) via a nucleophilic displacement of the haloacetate by a residue in the binding site of the protein. The covalently linked biotin will allow for a facile isolation and purification of the protein on a streptavidin column thus rendering the protein ready for a tryptic digest followed by mass spectrometric analysis. The 11-cis retinoid was synthesized via metal reduction of an alkyne intermediate generated from a Horner-Wadsworth-Emmons (HWE) reaction whereas the all-trans was synthesized via two consecutive HWE couplings.

Cloning, sequence analysis, and expression in Escherichia coli of the gene encoding monovalent cation-activated levodione reductase from Corynebacterium aquaticum M-13.

The gene encoding (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) reductase was cloned from the genomic DNA of the soil isolate bacterium Corynebacterium aquaticum M-13. The gene contained an open reading frame consisting of 801 nucleotides correspo