607-31-8

Basic information

• Product Name: 4-Methoxyquinoline
• Synonyms: 4-Methoxyquinoline
• CAS NO: 607-31-8
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• EINECS: -0
• Product Categories: pharmacetical
• Mol File: 607-31-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 41°C
• Boiling Point: 284.68°C (rough estimate)
• Flash Point: 89.7 °C
• Appearance: /
• Density: 1.1202 (rough estimate)
• Vapor Pressure: 0.0444mmHg at 25°C
• Refractive Index: 1.6070 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 6.37±0.13(Predicted)
• CAS DataBase Reference: 4-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxyquinoline(607-31-8)
• EPA Substance Registry System: 4-Methoxyquinoline(607-31-8)

Safety Data

• Hazardous Substances Data: 607-31-8(Hazardous Substances Data)

Usage

Uses

4-Methoxyquinoline is used as a reactant in the synthesis of hybrid quinoline-4-yloxadiazoles/oxathiadiazoles as potent antifungal agents.

InChI:InChI=1/C10H9NO/c1-12-10-6-7-11-9-5-3-2-4-8(9)10/h2-7H,1H3

Upstream product

• 14547-98-9 4-methoxyquinoline-N-oxide 
• 768-90-1 1-Adamantyl bromide 
• 26707-52-8 7-chloro-4-methoxyquinoline 
• 186581-53-3 diazomethane 
• 611-36-9 quinolin-4-ol 
• 67-56-1 methanol 
• 611-35-8 4-chloroquinoline 
• 865-33-8 potassium methanolate 
• 3964-04-3 4-bromoquinoline 
• 74-88-4 methyl iodide 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 86-98-6 4,7-dichloroquinoline 
• 15733-83-2 4-methoxyquinoline-2-carboxylic acid 
• 65148-06-3 N-((4-methylphenyl)sulfonyl)-N-phenyl-beta-alanine 

Downstream Products

• 14547-98-9 4-methoxyquinoline-N-oxide 
• 681827-50-9 benzyl 2-methyl-4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate 
• 54885-00-6 phenyl(quinolin-4-yl)methanone 
• 182951-14-0 4-Oxo-2-((Z)-7-phenylsulfanyl-hept-3-ene-1,5-diynyl)-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester 
• 182951-13-9 2-[2-(3-Hydroxy-prop-1-ynyl)-phenylethynyl]-4-oxo-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester 
• 83-54-5 1-methyl-4-quinolone 
• 13720-89-3 1-ethyl-1,4-dihydroquinolin-4-one 
• 66820-51-7 C₁₁H₁₂NO⁽¹⁺⁾*C₂H₆O₄P^(1-) 
• 93326-48-8 phenyl-quinolin-4-yl-acetonitrile 

Relevant articles and documents

Structure and synthesis of echinorin, an alkaloid from Echinops ritro L. and sphaerocephalus L. (Asteraceae)

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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma

A novel series of tricyclic tetrahydroquinolines were identified as potent and selective CRTh2 receptor antagonists. The agonism and antagonism switch was achieved through structure-based drug design (SBDD) using a CRTh2 receptor homologue model. The challenge of very low exposures in pharmacokinetic studies was overcome by exhaustive medicinal chemistry lead optimization through focused SAR studies on the tricyclic core. Further optimization resulted in the identification of the preclinical candidate 4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid (15c, MK-8318) with potent and selective CRTh2 antagonist activity and a favorable PK profile suitable for once daily oral dosing for potential treatment of asthma.

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.