60706-63-0

Basic information

• Product Name: 2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE
• Synonyms: BENZENESULFONYL CHLORIDE, 2,3,5,6-TETRAMETHYL-;2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE;2,3,5,6-TETRAMETHYLBENZENESULPHONYL CHLORIDE;TIMTEC-BB SBB005823;Benzenesulfonyl chloride, 2,3,5,6-tetramethyl- (7CI, 9CI);2,3,5,6-Tetramethylbenzenesulfonyl chloride,98%;2,3,5,6-Tetramethylbenzenesulfonyl cholride
• CAS NO: 60706-63-0
• Molecular Formula: C₁₀H₁₃ClO₂S
• Molecular Weight: 232.73
• Product Categories: SULFONYLHALIDE
• Mol File: 60706-63-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 97-101 °C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• Appearance: White to pale cream/Crystalline Powder
• Density: 1.217 g/cm³
• Vapor Pressure: 0.000137mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 1876644
• CAS DataBase Reference: 2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE(60706-63-0)
• EPA Substance Registry System: 2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE(60706-63-0)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-29-36
• Safety Statements: 45-36/37/39-26
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 60706-63-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13ClO2S/c1-6-5-7(2)9(4)10(8(6)3)14(11,12)13/h5H,1-4H3

Upstream product

• 95-93-2 1,2,4,5-tetramethylbenzene 

Downstream Products

• 1111005-04-9 1,2,4,5-tetramethyl-3-(2-phenylprop-2-en-1-ylsulfonyl)benzene 

Relevant articles and documents

Intermolecular 1,2-Difunctionalization of Alkenes Enabled by Fluoroamide-Directed Remote Benzyl C(sp3)-H Functionalization

A copper-catalyzed remote benzylic C-H functionalization strategy enabling 1,2-difunctionalization of alkenes with 2-methylbenzeneamides and nucleophiles, including alcohols, indoles, pyrroles, and the intrinsic amino groups, is reported, which is charact

Solvent network at the transition state in the solvolysis of hindered sulfonyl compounds

Alcoholysis rates of unhindered benzenesulfonyl chlorides (X-ArSO2Cl, X = H-; 4-Br-; 4-Me-) are similar in methanol; the same behavior is also observed in ethanol, whereas the reactivity order in iso-propanol is 4 Me- 2Cl) (X = 2,4,6-Me3-3-NO2-; 2,6-Me2-4-tBu-; 2,4,6-Me3-; 2,3,5,6-Me4-; 2,4,6-iPr3-; 2,4-Me2-; 2,4,6-(OMe)3-) in all studied alcohols show a significant increase in reactivity, the so-called positive steric effect. Most of the substrates showed a reaction order b ~ 2 with respect to the nucleophile in methanol and ethanol, and b ~ 3 in iso-propanol. The correlation between reactivity and the Kirkwood function (1/ξ) gives negative sensitivity (U) for all systems. All substrates showed high sensitivity to media nucleophilicity that depends on ΣσX. Obtained results suggest the alcoholysis of benzenesulfonyl chlorides proceeds through SN2 mechanism where the transition state (TS) involves the participation of 2–3 alcohol molecules; such a TS can be cyclic, in the case of unbranched alcohols, or linear, for alcohols with bulkier hydrocarbon groups like iso-propanol. To include the number of alcohol molecules playing such a role in the TS, the following terminology is proposed: cSN2sn for SN2 reactions involving n solvent molecules in a cyclic (c) TS, where “s” stands for the solvent and “n” is either the closest integer or half-integer to the reaction order relative to the solvent or, in computational studies, the proposed number of solvent molecules taking part in the TS, whereas SN2sn is proposed when the TS is not cyclic. Copyright