60719-13-3Relevant articles and documents
Catalytic Asymmetric Homologation of 4-Substituted Cyclohexanones with CF3CHN2: Enantioselective Synthesis of α-Trifluoromethyl Cycloheptanones
Li, Shu-Sen,Sun, Shuo,Wang, Jianbo
supporting information, (2021/12/27)
Introduction of the trifluoromethyl group (CF3) into organic molecules in an enantioselective manner has attracted significant attention, but still remains a challenging problem. We herein report a catalytic asymmetric trifluoromethylation of cyclic ketones via a ScIII/chiral bisoxazoline-catalyzed homologation reaction by employing 2,2,2-trifluorodiazoethane (CF3CHN2) as the CF3 source. This desymmetrization process is highly efficient and generates two chiral centers with excellent diastereoselectivity and enantioselectivity, affording chiral α-trifluoromethyl cyclic ketones in a straightforward manner.
Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones: Via consecutive β-F elimination and C-F bond activation
Xu, Lei,Zhang, Qi,Xie, Qiang,Huang, Bei,Dai, Jian-Jun,Xu, Jun,Xu, Hua-Jian
, p. 4406 - 4409 (2018/05/03)
An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C-F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C-F bond activation.
Synthesis of trifluoroethyl-substituted ketones from aldehydes and cyclohexanones
Morandi, Bill,Carreira, Erick M.
supporting information; experimental part, p. 9085 - 9088 (2011/10/13)
A trifluoromethylated symphony! A new transformation involving trifluoromethyl diazomethane generated in situ has been developed that allows direct access to trifluoroethyl ketone derivatives from aldehyde and cyclohexanone compounds (see scheme). Copyright
