607356-44-5

Basic information

• Product Name: 3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid
• Synonyms: 3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid
• CAS NO: 607356-44-5
• Molecular Weight: 364.384
• Mol File: 607356-44-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid(607356-44-5)
• EPA Substance Registry System: 3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid(607356-44-5)

Safety Data

• Hazardous Substances Data: 607356-44-5(Hazardous Substances Data)

Upstream product

• 14949-00-9 5-amino-1, 3, 4-thiadiazole-2-sulfonamide 
• 4025-64-3 3-Carboxybenzenesulfonyl chloride 

Downstream Products

• 1033598-26-3 C₁₃H₁₅N₅O₉S₃ 
• 1033598-36-5 C₂₃H₂₃N₅O₁₂S₃ 

Relevant articles and documents

Carbonic anhydrase inhibitors: Topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide

Reaction of 3- and 4-carboxybenzenesulfonyl chloride with 5-amino-1,3,4-thiadiazole-2-sulfonamide/5-imino-4-methyl-δ 2-1,3,4-thiadiazoline-2-sulfonamide afforded two series of benzolamide analogues to which the carboxyl moiety has been derivatized as esters or amides, in order to reduce their very polar character. The new derivatives showed low nanomolar affinity for three carbonic anhydrase (CA) isozymes, CA I, II and IV, and were effective as topical antiglaucoma agents in normotensive rabbits. Efficacy of several of the new sulfonamides reported was better than that of the standard drugs dorzolamide and brinzolamide, whereas their duration of action was prolonged as compared to that of the clinically used drugs.