607376-67-0Relevant articles and documents
A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin
Garner, Philip,Weerasinghe, Laksiri,Van Houten, Ian,Hu, Jieyu
, p. 4908 - 4910 (2014/05/06)
A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.
NOVEL BICYCLIC COMPOUNDS
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, (2011/04/24)
The invention is concerned with novel bicyclic compounds of formula (I), wherein A, L, E, F, G, R1, R2, R3, R4, R5, R6, R7, V, W and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.
Useful synthesis of 2,3,6-tri- and 2,3,5,6-tetrasubstitutedpyridine derivatives from aspartic acid
Yonezawa, Yasuchika,Konn, Akihito,Shin, Chung-gi
, p. 2735 - 2746 (2007/10/03)
New synthetic methods for 2,3,6-tri- and 2,3,5,6-tetrasubstituted pyridineskeletons, which are the essential main central segments of thiostrepton-type macrocyclic antibiotics, were developed from l-α-aspartic acid (Asp) via the Asp-derived α-dehydroamino