60744-45-8

Basic information

• Product Name: 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid
• Synonyms: 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid
• CAS NO: 60744-45-8
• Molecular Weight: 273.329
• Mol File: 60744-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid(60744-45-8)
• EPA Substance Registry System: 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid(60744-45-8)

Safety Data

• Hazardous Substances Data: 60744-45-8(Hazardous Substances Data)

Upstream product

• 98-89-5 Cyclohexanecarboxylic acid 
• 98265-88-4 phenylmethyl 2-[(2,2-dimethoxyethyl)amino]acetate 
• 406954-87-8 phenylmethyl 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetate 

Downstream Products

• 406954-88-9 N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 

Relevant articles and documents

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

Bicyclization of peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was explored as a route to novel amino acid derived heterocycles and peptidomimetic scaffolds. In the presence of protic acid, bridged structures such as 6 are formed readily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yield. In contrast, radical cyclization of the bromophenyl dihydropyrazinone 7 provides an effective alternative for the synthesis of 5 (n = 0, 1, 2). Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8.