608-50-4Relevant articles and documents
Synthesis of 2, 4, 6-trimethyl of lentine method (by machine translation)
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Paragraph 0015; 0019; 0020, (2016/11/14)
The present invention relates to synthesis of 2, 4, 6-trimethyl of lentine method, characterized in that comprises the following steps : (1) in trimethyl benzene to nitration instillment nitration mixture generating 2, 4, 6-trimethyl-dinitrobenzene, after the completion of reaction, static layer, the organic layer obtained by and water washing in 2, 4, 6-trimethyl-dinitrobenzene ; (2) the step (1) of the 2, 4, 6-trimethyl-dinitrobenzene by adding high pressure autoclave, then adding catalyst and solvent, nitrogen, hydrogen replacing the air in the high-pressure autoclave, through hydrogen hydrogenation reduction generating 2, 4, 6-trimethyl lentine; the hydrogenation reduction temperature is 50-120°C, the catalyst is a nickel catalyst; after the end of the hydrogenation discharge hydrogen, methanol is removed after discharging, the cooling crystallization, filtering to obtain the 2, 4, 6-trimethyl metaphenylene diamine. The synthetic route of this invention is short, the product has high purity, high yield, few reaction steps, the hydrogen reduction catalyst for a long period of use. (by machine translation)
Sulfuric acid on silica-gel: An inexpensive catalyst for aromatic nitration
Riego, Juan M.,Sedin, Zeno,Zaldivar, Jose M.,Marziano, Nunziata C.,Tortato, Claudio
, p. 513 - 516 (2007/10/02)
Solid acidic catalysts made of sulfuric acid supported on silica-gel and their application to the nitration of aromatics with nitric acid and isopropyl nitrate are described. Substrates with very different levels of activation were investigated. Methods to overcome the poisoning produced by water and to tune the catalysts activity according to the reactivity of the substrate are outlined.
Ozone-mediated Nitration of Alkylbenzenes and Related Compounds with Nitrogen Dioxide
Suzuki, Hitomi,Murashima, Takashi,Kozai, Iku,Mori, Tadashi
, p. 1591 - 1598 (2007/10/02)
In the presence of ozone, nitrogen dioxide exhibits a strong nitrating ability for alkylbenzenes at low temperatures, converting them into the corresponding nitro derivatives in high yield.The addition of a protonic acid as catalyst enhances considerably the ability of this nitrating system and leads to a good yield of polynitro compounds.The reaction is clean and proceeds rapidly without any accompanying side-chain substitution or aryl-aryl coupling.It shows no kinetic dependence on the concentration of substrates and, as far as can be judged from relative reactivities and isomer distributions of products, it gives the appearance of being an electrophilic aromatic process.A possible role for nitrogen trioxide has been suggested as the initial electrophilic agent for the nitration of alkylbenzenes.