6081-87-4

Basic information

• Product Name: 2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE
• Synonyms: ART-CHEM-BB B015555;AKOS B015555;2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE;TIMTEC-BB SBB007068;2-Chloro-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-acetamide;2-chloro-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]ethanamide;2-chloro-N-[4-(4-methylphenyl)-2-thiazolyl]acetamide;2-chloro-N-[4-(4-methylphenyl)thiazol-2-yl]acetamide
• CAS NO: 6081-87-4
• Molecular Formula: C₁₂H₁₁ClN₂OS
• Molecular Weight: 266.75
• Mol File: 6081-87-4.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Density: 1.346g/cm³
• Refractive Index: 1.638
• CAS DataBase Reference: 2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE(6081-87-4)
• EPA Substance Registry System: 2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE(6081-87-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6081-87-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11ClN2OS/c1-8-2-4-9(5-3-8)10-7-17-12(14-10)15-11(16)6-13/h2-5,7H,6H2,1H3,(H,14,15,16)

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 79-04-9 chloroacetyl chloride 
• 122-00-9 para-methylacetophenone 
• 619-41-0 4-(bromoacetyl)toluene 
• 2103-91-5 2-amino-4-(p-methylphenyl)-1,3-thiazole 

Downstream Products

• 380477-90-7 2-((4-(p-tolyl)thiazol-2-ylcarbamoyl)methylthio)acetic acid 

Relevant articles and documents

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors

A novel series of phenoxymethybenzoimidazole derivatives (9a-n) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89?μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0?μM). Enzyme kinetic studies on 9c, 9g, and 9m as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzoimidazole and triazole rings of the synthesized compounds to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor.

Β - secretase enzyme has the function of inhibiting compound, the preparation of the compounds and use thereof

The invention discloses a compound capable of inhibiting beta-secretase, and a preparation method and application thereof. The structure of the compound is shown in a formula I, formula II or formula III as described in the specification. In the formula I, X is S or NH; R1 is selected from hydrogen and nitro group; R2 and R4 are same or different and independently selected from the group consisting of hydrogen, halogen, nitro group and substituted aryl group; R3 is selected from the group consisting of hydrogen, nitro group, straight-chain and branched-chain alkyl and substituted alkyl groups with a carbon number of 1 to 4, alkylamino or alkyloxy group with a carbon number of 1 to 4 and alkylamido group with a carbon number of 1 to 4; R is located at position 2, 3 or 4 of a benzene ring and selected from the group consisting of hydrogen, straight-chain and branched-chain alkyl and substituted alkyl groups with a carbon number of 1 to 4, alkylamino or alkyloxy group with a carbon number of 1 to 4 and alkylamido group with a carbon number of 1 to 4. In the formula II, R is selected from different substituted aryl groups. In the formula III, R is selected from hydrogen or cyano group. Experiments prove that the compound provided by the invention has good beta-secretase inhibitory activity and has wide application values as a beta-secretase inhibitor.

New N-4 piperazinyl derivatives of norfloxacin: design, synthesis, and correlation of calculated physicochemical parameters with antibacterial activity

A group of N?4 piperazinyl derivatives of norfloxacin was synthesized and identified by different spectroscopic techniques. The N?4 piperazinyl substituent in target compounds 2a–2k, 3a–3c, and 4a and 4b was designed to have different electronic, steric,