608141-43-1Relevant articles and documents
METHODS FOR THE TREATMENT OF OBESITY USING APREMILAST
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Paragraph 0081, (2019/05/22)
Methods of treating, managing or preventing obesity and overweight are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.
NOVEL PROCESS FOR THE PREPARATION OF 1-(3-ETHOXY-4-METHOXY-PHENYL)-2-METHYLSULFONYL-ETHANAMINE
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Page/Page column 12, (2018/04/17)
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C4)haloalkyl, -O(C1-C4)alkyl, or –O-benzyl, and L is a leaving group.
NOVEL PROCESS FOR PREPARATION OF APREMILAST
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Page/Page column 15, (2018/02/03)
The present invention related to a novel compound of Formula II, its enantiomers or acid addition salts thereof and process for its preparation. The compound of Formula II can be used for preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide also known as apremilast.