60833-08-1Relevant articles and documents
PCSK9 ANTAGONIST COMPOUNDS
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, (2021/03/05)
Disclosed are compounds of Formula (A), or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
A NOVEL SYNTHESIS OF THE CARBAPEN-2-EM DERIVATIVES
Hatanaka, Minoru,Yamamoto, Yu-ichi,Nitta, Hajime,Ishimaru, Toshiyasu
, p. 3883 - 3886 (2007/10/02)
A new synthesis of the carbapen-2-em ring system, the basic nucleus of thienamycin and its relatives, is described.