60846-15-3

Basic information

• Product Name: ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE
• Synonyms: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, ETHYL ESTER;4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, ETHYL ESTER, (AZ)-;ATE;ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE;ETHYL-2-METHOXY-AMINO-2-(2-AMINO-THIAZOLE-4-YL) ACETATE;ETHYL (2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ACETATE;ETHYL (Z)-2-(2-AMINO-4-THIAZOLYL)-2-METHOXYIMINOACETATE;ethyl 2-amino-alpha-(methoxyimino)thiazol-4-acetate
• CAS NO: 60846-15-3
• Molecular Formula: C₈H₁₁N₃O₃S
• Molecular Weight: 229.26
• EINECS: 262-470-5
• Mol File: 60846-15-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 162-164 °C(lit.)
• Boiling Point: 363.4°C at 760 mmHg
• Flash Point: 173.6°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 1.81E-05mmHg at 25°C
• Refractive Index: 1.606
• PKA: 2.57±0.10(Predicted)
• Water Solubility: may decompose
• CAS DataBase Reference: ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE(60846-15-3)
• EPA Substance Registry System: ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE(60846-15-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 60846-15-3(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE is a chemical compound with the molecular formula C10H12N4O3S. It belongs to the class of aminothiazole compounds and is commonly used in pharmaceutical and research applications. ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE is a derivative of aminothiazole, which is known for its potential biological activity. It is a methoxyiminoacetate ester, characterized by a methoxyimino group attached to the carbon atom in the acetic acid moiety. Its structure and properties make it a valuable building block for the synthesis of novel pharmaceutical compounds and is of interest for medicinal chemistry research.

InChI:InChI=1/C8H11N3O3S/c1-3-14-7(12)6(11-13-2)5-4-15-8(9)10-5/h4H,3H2,1-2H3,(H2,9,10)/b11-6+

Upstream product

• 64485-87-6 ethyl 2-methoxyimino-3-oxo-4-chlorobutyrate 
• 17356-08-0 thiourea 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 60845-81-0 ethyl 2-amino-α-(hydroxyimino)-4-thiazole acetate 
• 77-78-1 dimethyl sulfate 
• 64485-88-7 ethyl 2-(2-aminothiazol-4-yl)-2-(anti)-methoxyiminoacetate 

Downstream Products

• 94088-75-2 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one 
• 1456776-33-2 ethyl 2-(2-((diethoxyphosphoryl)(4-(dimethylamino)phenyl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-32-1 ethyl 2-(2-((diethoxyphosphoryl)(3,4-dimethoxyphenyl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-36-5 ethyl 2-(2-((4-chlorophenyl)(diethoxyphosphoryl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-31-0 ethyl 2-(2-((2-(benzyloxy)phenyl)(diethoxyphosphoryl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-34-3 ethyl 2-(2-((diethoxyphosphoryl)(4-hydroxyphenyl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-29-6 ethyl 2-(2-((diethoxyphosphoryl)(3-nitrophenyl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-38-7 ethyl 2-(2-((2,4-dichlorophenyl)(diethoxyphosphoryl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 
• 1456776-37-6 ethyl 2-(2-((4-chloro-3-nitrophenyl)(diethoxyphosphoryl)methylamino)thiazol-4-yl)-2-(methoxyimino)acetate 

Relevant articles and documents

Continuous flow synthesis method of 2-(2-aminothiazole-4-yl)-2-methoxyiminoacetic acid intermediate

The invention discloses a continuous flow synthesis method of an 2-(2-aminothiazole-4-yl)-2-methoxyiminoacetic acid intermediate, and belongs to the technical field of organic synthesis. The method comprises the following steps: (1) enabling 2-methoxyimino ethyl acetoacetate to pass through a material channel A of a continuous flow microreactor, enabling sulfonyl chloride to pass through a material channel B, enabling a catalyst and an initiator to pass through a material channel C and respectively flow into a reaction channel with a preset temperature through metering pumps P1, P2 and P3 formixing reaction, and enabling reaction liquid to flow out from a discharge port after the reaction is finished; and (2) after the reaction liquid flows out, dropwise adding the reaction liquid into athiourea aqueous solution, controlling the pH value to react, adjusting the pH value to be neutral after the reaction is finished, cooling, filtering, washing and drying to obtain the 2-(2-aminothiazole-4-yl)-2-methoxyiminoacetic acid. By using the continuous flow microreactor, the continuous reaction is realized, the process is stable and easy to control, the reaction toxicity is low, the yield can reach 92.94%, and the product purity can reach 99.55%.

The jig measuring method for measuring the shape of the film surface,

PROBLEM TO BE SOLVED: To provide a fixing tool for measuring a film surface shape and a method of measuring the film surface shape for suppressing the influence of a film fixing method and the like on the measurement data to the minimum, when quantitatively measuring film surface shape. SOLUTION: The fixing tool for measuring film surface shape, being the film fixing tool used when measuring the shape of film surface or the shape of a structure formed on the film surface has: a mechanism for holding the circumference of the measuring area of the film surface from both top and bottom directions of the film; and a mechanism for pulling it in both outward directions of the XY plane of the film. Preferably, the mechanism for holding the film from both top and bottom directions of the film is so constituted that a fixing tool made of parallel flat plates holds the film from both the top and bottom. COPYRIGHT: (C)2010,JPOandINPIT