608520-05-4

Basic information

• Product Name: (3R,2S)-3-propyloxirane-2-carboxylic acid
• Synonyms: (3R,2S)-3-propyloxirane-2-carboxylic acid
• CAS NO: 608520-05-4
• Molecular Weight: 130.144
• Mol File: 608520-05-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3R,2S)-3-propyloxirane-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,2S)-3-propyloxirane-2-carboxylic acid(608520-05-4)
• EPA Substance Registry System: (3R,2S)-3-propyloxirane-2-carboxylic acid(608520-05-4)

Safety Data

• Hazardous Substances Data: 608520-05-4(Hazardous Substances Data)

Upstream product

• 92418-71-8 (2R,3R)-2,3-epoxy-1-hexanol 

Downstream Products

• 791855-90-8 (4-Benzyl-piperazin-1-yl)-((2S,3R)-3-propyl-oxiranyl)-methanone 
• 1166397-39-2 (2S,3S) 3-amino-2-hydroxy-hexanoyl cyclopropylamide hydrochloride salt 
• 160801-75-2 (-)-(2S,3S)-3-amino-2-hydroxyhexanoic acid 

Relevant articles and documents

Solid-Phase Total Synthesis of Dehydrotryptophan-Bearing Cyclic Peptides Tunicyclin B, Sclerotide A, CDA3a, and CDA4a using a Protected β-Hydroxytryptophan Building Block

A new approach to the synthesis of Z-dehydrotryptophan (ΔTrp) peptides is described. This approach uses Fmoc-β-HOTrp(Boc)(TBS)-OH as a building block, which is readily prepared in high yield and incorporated into peptides using solid-phase Fmoc chemistry. The tert-butyldimethylsilyl-protected indolic alcohol is eliminated during global deprotection/resin cleavage to give ΔTrp peptides exclusively as the thermodynamically favored Z isomer. This approach was applied to the solid-phase synthesis of tunicyclin B, sclerotide A, CDA3a, and CDA4a.

Synthesis of an intermediate of an antiviral compound

Process for the preparation of a cyclopropylamide compound (II) which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.