608532-81-6

Basic information

• Product Name: 1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one
• Synonyms: 1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one
• CAS NO: 608532-81-6
• Molecular Weight: 289.375
• Mol File: 608532-81-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one(608532-81-6)
• EPA Substance Registry System: 1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one(608532-81-6)

Safety Data

• Hazardous Substances Data: 608532-81-6(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 608532-80-5 1,4,4-trichloro-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one 
• 608532-79-2 2,2,2-trichloro-N-(cyclohexylidenemethyl)-N-(4-methoxybenzyl)acetamide 
• 219915-83-0 [1-Cyclohexyl-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 64744-50-9 gabapentin-lactam 
• 608532-82-7 2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one 

Relevant articles and documents

Metal-catalysed radical cyclisations leading to N-heterocycles: New approaches to gabapentin and pulchellalactam

The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam.