6087-94-1 Usage
Description
Bis(2-chloroethyl) chlorophosphate, also known as 2-chloro-ethanol phosphorochloridate, is an intermediate compound used in the synthesis of various organic compounds. It is a chlorinated organophosphate with the chemical formula C4H8Cl3O2P. bis(2-chloroethyl) chlorophosphate is known for its reactivity and is commonly utilized in the production of pharmaceuticals and other chemical substances.
Uses
Used in Pharmaceutical Industry:
Bis(2-chloroethyl) chlorophosphate is used as an intermediate in the synthesis of Di-β,β''-Chloroethylphosphoric Acid (C366790) for its role in creating dialkyl hydrogen phosphates. These dialkyl hydrogen phosphates can undergo electrophilic trifluoromethylation, which leads to the production of trifluoromethyl phosphates. The addition of trifluoromethyl phosphates increases the lipophilicity of functional groups, enhancing the overall properties and effectiveness of the final pharmaceutical product.
Used in Chemical Synthesis:
In the chemical industry, bis(2-chloroethyl) chlorophosphate is used as a versatile building block for the creation of various organic compounds. Its reactivity with different functional groups allows for the development of a wide range of products, from pharmaceuticals to agrochemicals and other specialty chemicals. bis(2-chloroethyl) chlorophosphate's ability to participate in electrophilic trifluoromethylation reactions makes it a valuable asset in the synthesis of novel molecules with improved properties.
Check Digit Verification of cas no
The CAS Registry Mumber 6087-94-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,8 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6087-94:
(6*6)+(5*0)+(4*8)+(3*7)+(2*9)+(1*4)=111
111 % 10 = 1
So 6087-94-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H8Cl3O3P/c5-1-3-9-11(7,8)10-4-2-6/h1-4H2
6087-94-1Relevant articles and documents
Shner et al.
, p. 1856,1860 (1965)
Reactivity of an electrophilic hypervalent iodine trifluoromethylation reagent with hydrogen phosphates - A mechanistic study
Santschi, Nico,Geissbühler, Patrik,Togni, Antonio
experimental part, p. 83 - 86 (2012/03/27)
The electrophilic trifluoromethylation of hydrogen phosphates with the reagent trifluoromethyl-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole (1) was studied by means of initial rates determined for pseudo first order setups and subsequent Taft analysis of the calculated relative rates. A positive polar sensitivity factor, indicative of a negative charge forming during the rate-determining step, was found for the whole data set.
Process for preparing bis(2-haloalkyl) phosphoro-halidates
-
, (2008/06/13)
An improved process is disclosed for the preparation of bis(2-haloalkyl) phosphorohalidates. This process comprises the steps of reacting phosphorus trihalide with a stoichiometric excess of alkylene oxide to form tris(2-haloalkyl) phosphite, substantially eliminating the presence of unreacted alkylene oxide in the tris(2-haloalkyl) phosphite, and finally converting it to bis(2-haloalkyl) phosphorohalidate by reaction with halogen.
