609-46-1Relevant articles and documents
Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines
Aksenov, Alexander V.,Domenyuk, Dmitriy A.,Magometov, Artyom Yu.,Rubin, Michael,Shcherbakov, Stanislav S.,Shcherbakova, Viktoriia Yu.,Zelensky, Vladimir A.
, p. 10315 - 10321 (2020)
A new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Br?nsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization of the formed dihydropyrimidine ring. Finally, palladium-catalyzed Sonogashira cross-coupling reaction provided an end-game strategy.
Process for preparing a synthetic aluminium tanning agent
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, (2008/06/13)
A novel synthetic aluminium tanning agent as an alternative for chromium based tanning salts without using formaldehyde was prepared by using aromatic polymeric matrix and aluminium (III) salts as raw materials with suitable masking agents. The preparation of the syntan consists of sulphonation of aromatic molecule, which is incorporated with a polymeric network along with ligands specially designed for the complexation of aluminium (III) salts. The complex can be used as a self-tanning agent in leather industry with fairly good filling behavior. The tanned leathers exhibit shrinkage temperature about 85° C. Due to the higher precipitation point of the product, it can be used for tanning directly after deliming thus eliminating the pickling process. This product, unlike the conventional phenol based products, does not undergo photo-oxidation thereby preventing the discoloration of the tanned leathers.
THE DESULFONATION OF PHENOLSULFONIC ACIDS IN AQUEOUS SODIUM HYDROGEN SULFATE MIXTURES
Jason, Mark E.
, p. 55 - 64 (2007/10/02)
Phenol and phenolsulfonic acids are rapidly sulfonated and desulfonated in aqueous sodium hydrogen sulfate, with or without added sulfuric acid.At temperatures above 130 deg C, desulfonation competes with sulfonation sufficiently to allow steam stripping of phenol from the reaction mixtures, even under conditions of low water content.Above 170 deg C removal of phenol is less efficient because the water content is very low and the predominant species in the reaction mixture is 2,4,6-phenoltrisulfonate.Key words: Phenol; phenolsulfonic acid sulfonation; desulfonation; sodium hydrogen sulfate; kinetics; HPLC.