60901-27-1

Basic information

• Product Name: N-(4-chlorophenyl)ethanesulfonamide
• Synonyms: N-(4-chlorophenyl)ethanesulfonamide
• CAS NO: 60901-27-1
• Molecular Formula: C₈H₁₀ClNO₂S
• Molecular Weight: 219.6885
• Mol File: 60901-27-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-chlorophenyl)ethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)ethanesulfonamide(60901-27-1)
• EPA Substance Registry System: N-(4-chlorophenyl)ethanesulfonamide(60901-27-1)

Safety Data

• Hazardous Substances Data: 60901-27-1(Hazardous Substances Data)

Usage

Description

N-(4-chlorophenyl)ethanesulfonamide, also known as tolmesoxide, is a sulfonamide-based compound that functions as a nonsteroidal anti-inflammatory drug (NSAID). It is recognized for its analgesic and anti-inflammatory properties, which are utilized in the management of conditions such as osteoarthritis, rheumatoid arthritis, and other inflammatory disorders. The mechanism of action involves the inhibition of prostaglandin production, thereby reducing inflammation and pain.

Uses

Used in Pharmaceutical Industry:
N-(4-chlorophenyl)ethanesulfonamide is used as an analgesic and anti-inflammatory agent for the treatment of various inflammatory conditions. It is effective in managing pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other similar disorders due to its ability to inhibit prostaglandin synthesis.
Used in Medical Treatment:
As a nonsteroidal anti-inflammatory drug, N-(4-chlorophenyl)ethanesulfonamide is used in medical treatment to alleviate symptoms of inflammation and pain. It is available in different forms such as tablets, capsules, and suspension for oral administration, providing flexibility in treatment options for patients.
It is crucial to administer N-(4-chlorophenyl)ethanesulfonamide under the guidance of a healthcare professional to monitor for potential side effects and drug interactions, ensuring the safe and effective use of this medication.

Upstream product

• 106-47-8 4-chloro-aniline 
• 594-44-5 Ethanesulfonyl chloride 

Downstream Products

• 23091-53-4 Ethanesulfonic acid (4-chloro-phenyl)-(1,1,2,2-tetrachloro-2-fluoro-ethylsulfanyl)-amide 

Relevant articles and documents

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).

Amide compound for prevention and treatment of mental disorders

The present invention relates to an amide compound for prevention and treatment of mental disorders, which is shown as a formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a solvate thereof, a deuterated substance or a stereoisomer thereof. Wherein R1, R2, R3, R4, R5, Ar1, Ar2, p and q are as defined in the specification. The invention also relates to a preparation methodof the amide compound, a pharmaceutical composition and a pharmaceutical preparation containing the amide compound, and an application of the compound in preparation of a drug for prevention or treatment of mental disorders such as depression, depression and anxiety, and schizophrenia.