609347-32-2

Basic information

• Product Name: 3-chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamine
• Synonyms: 3-chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamine
• CAS NO: 609347-32-2
• Molecular Weight: 253.755
• Mol File: 609347-32-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamine(609347-32-2)
• EPA Substance Registry System: 3-chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamine(609347-32-2)

Safety Data

• Hazardous Substances Data: 609347-32-2(Hazardous Substances Data)

Upstream product

• 35170-78-6 1,5-dimethyl-1,3-dihydro-imidazole-2-thione 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Relevant articles and documents

Synthesis and evaluation of 4-anilino-6, 7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-6, 7-diethoxy-3-quinolinecarbonitrile (3) was identified as a MEK1 kinase inhibitor with exceptional activity against LoVo cells. The structure-activity relationships of the C-4 aniline substituents were explored, and water-solubilizing groups were added at the C-7 position to improve physical properties. Secondary cellular assays revealed that a compound possessing the appropriate aniline substituents inhibited MEK1 as well as MAPK phosphorylation, thereby acting as a dual inhibitor of the Ras-MAPK signaling cascade.